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Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease
Tan, Y.; Liu, Y.; Liu, Y.; Ma, R.; Luo, J.; Hong, H.; Chen, X.; Wang, S.; Liu, C.; Zhang, Y.; Chen, T.
2021-11-19
Source PublicationResearch
ISSN2639-5274
Pages9812523-9812523
AbstractMitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease (PD), presenting within the form of excessive reactive oxygen species (ROS) generation as well as energy metabolism. Overcoming this dysfunction within brain tissues is an effective approach to treat PD, while unluckily, the blood-brain barrier (BBB) substantially impedes intracerebral drug delivery. In an effort to improve the delivery of efficacious therapeutic drugs to the brain, a drug delivery platform hydrogel (MAG-NCs@Gel) was designed by complexing magnolol (MAG)-nanocrystals (MAG-NCs) into the noninvasive thermosensitive poly(N-isopropylacrylamide) (PNIPAM) with self-gelation. The as-prepared MAG-NCs@Gel exhibited obvious improvements in drug solubility, the duration of residence with the nasal cavity, and the efficiency of brain targeting, respectively. Above all, continuous intranasal MAG-NCs@Gel delivery enabled MAG to cross the BBB and enter dopaminergic neurons, thereby effectively alleviating the symptoms of MPTP-induced PD. Taking advantage of the lower critical solution temperature (LCST) behavior of this delivery platform increases its viscoelasticity in nasal cavity, thus improving the efficiency of MAG-NCs transit across the BBB. As such, MAG-NCs@Gel represented an effective delivery platform capable of normalizing ROS and adenosine triphosphate (ATP) in the mitochondria of dopaminergic neurons, consequently reversing the mitochondrial dysfunction and enhancing the behavioral skills of PD mice without adversely affecting normal tissues.
KeywordN/A
URLView the original
Language英語English
The Source to ArticlePB_Publication
PUB ID62357
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang, Y.; Chen, T.
Recommended Citation
GB/T 7714
Tan, Y.,Liu, Y.,Liu, Y.,et al. Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease[J]. Research,2021:9812523-9812523.
APA Tan, Y.,Liu, Y.,Liu, Y.,Ma, R.,Luo, J.,Hong, H.,Chen, X.,Wang, S.,Liu, C.,Zhang, Y.,&Chen, T..(2021).Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease.Research,9812523-9812523.
MLA Tan, Y.,et al."Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease".Research (2021):9812523-9812523.
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