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Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A
Yang, Chao1; Li, Dan2; Zang, Shaohong1; Zhang, Lei3; Zhong, Zhangfeng4; Zhou, Yingtang1
2022-07-19
Source PublicationFrontiers in Pharmacology
Volume13
Abstract

Epigenetics has emerged as a prime focus area in the field of cancer research. Lysine-specific demethylase 1A (LSD1), the first discovered histone demethylase, is mainly responsible for catalysing demethylation of histone 3 lysine 4 (H3K4) and H3K9 to activate or inhibit gene transcription. LSD1 is abnormally expressed in various cancers and participates in cancer proliferation, apoptosis, metastasis, invasion, drug resistance and other processes by interacting with regulatory factors. Therefore, it may serve as a potential therapeutic target for cancer. This review summarises the major oncogenic mechanisms mediated by LSD1 and provides a reference for developing novel and efficient anticancer strategies targeting LSD1.

KeywordAnticancer Activity Demethylation Epigenetics Histone Modifications Lsd1 Lysine Methylation Signaling Pathway Targets
DOI10.3389/fphar.2022.955218
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000835480500001
Scopus ID2-s2.0-85135232602
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhong, Zhangfeng; Zhou, Yingtang
Affiliation1.National Engineering Research Center for Marine Aquaculture, Institute of Innovation and Application, Zhejiang Ocean University, Zhoushan, China
2.State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3.Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Canada
4.Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese 10 Medical Sciences, University of Macau, Macao
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Chao,Li, Dan,Zang, Shaohong,et al. Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A[J]. Frontiers in Pharmacology,2022,13.
APA Yang, Chao,Li, Dan,Zang, Shaohong,Zhang, Lei,Zhong, Zhangfeng,&Zhou, Yingtang.(2022).Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A.Frontiers in Pharmacology,13.
MLA Yang, Chao,et al."Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A".Frontiers in Pharmacology 13(2022).
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