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An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis
Li, Jingjing1; Li, Renkai2; Wu, Xiaoping2; Zheng, Chengwen2; Shiu, Polly Ho Ting2; Rangsinth, Panthakarn2; Lee, Simon Ming Yuen3; Leung, George Pak Heng2
2022-07-19
Source PublicationFrontiers in Pharmacology
Volume13
Abstract

Angiogenesis, the formation of new capillaries from pre-existing vascular networks, plays an important role in many physiological and pathological processes. The use of pro-angiogenic agents has been proposed as an attractive approach for promoting wound healing and treating vascular insufficiency-related problems, such as ischemic heart disease and stroke, which are the leading causes of death worldwide. Traditional herbal medicine has a long history; however, there is still a need for more in-depth studies and evidence-based confirmation from controlled and validated trials. Many in vitro and in vivo studies have reported that herbal medicines and their bioactive ingredients exert pro-angiogenic activity. The most frequently studied pro-angiogenic phytochemicals include ginsenosides from Panax notoginseng, astragalosides and calycosin from Radix Astragali, salvianolic acid B from Salvia miltiorrhiza, paeoniflorin from Radix Paeoniae, ilexsaponin A1 from Ilex pubescens, ferulic acid from Angelica sinensis, and puerarin from Radix puerariae. This review summarizes the progress in research on these phytochemicals, particularly those related to pro-angiogenic mechanisms and applications in ischemic diseases, tissue repair, and wound healing. In addition, an outline of their limitations and challenges during drug development is presented.

KeywordHerbal Medicine Ischemic Diseases Phytochemicals Pro-angiogenic Wound Healing
DOI10.3389/fphar.2022.928817
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000835106200001
Scopus ID2-s2.0-85135212494
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Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorLeung, George Pak Heng
Affiliation1.Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Kowloon, Hong Kong
2.Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong
3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
Recommended Citation
GB/T 7714
Li, Jingjing,Li, Renkai,Wu, Xiaoping,et al. An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis[J]. Frontiers in Pharmacology,2022,13.
APA Li, Jingjing,Li, Renkai,Wu, Xiaoping,Zheng, Chengwen,Shiu, Polly Ho Ting,Rangsinth, Panthakarn,Lee, Simon Ming Yuen,&Leung, George Pak Heng.(2022).An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis.Frontiers in Pharmacology,13.
MLA Li, Jingjing,et al."An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis".Frontiers in Pharmacology 13(2022).
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