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Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson's Disease
Wang, Qun1; Ma, Rui1; Liu, Piaoxue1; Cheng, Guowang2; Yang, Qi3; Chen, Xiaojia3; Wu, Zhenfeng2; Yuan, Dongsheng1; Chen, Tongkai1
2022-08-18
Source PublicationPharmaceutics
ISSN1999-4923
Volume14Issue:8Pages:1731
Abstract

Parkinson’s disease (PD) is a serious neurodegenerative disease wherein the progressive destruction of dopaminergic neurons results in a series of related movement disorders. Effective oral delivery of anti-Parkinson’s drugs is challenging owing to the blood-brain barrier (BBB) and the limited plasma exposure. However, polymeric nanoparticles possess great potential to enhance oral bioavailability, thus improving drug accumulation within the brain. In this work, biodegradable poly(ethylene glycol)-b-poly(trimethylene carbonate) (PEG-PTMC) nanoparticles (PPNPs) were developed to deliver Ginkgolide B (GB) as a potent treatment for PD, aiming to enhance its accumulation within both the blood and the brain. The resultant GB-PPNPs were able to facilitate sustained GB release for 48 h and to protect against 1-methyl-4-phenylpyridine (MPP+)-induced neuronal cytotoxicity without causing any toxic damage. Subsequent pharmacokinetic studies revealed that GB-PPNPs accumulated at significantly higher concentrations in the plasma and brain relative to free GB. Oral GB-PPNP treatment was also linked to desirable outcomes in an animal model of PD, as evidenced by improvements in locomotor activity, levels of dopamine and its metabolites, and tyrosine hydroxylase activity. Together, these data suggest that PPNPs may represent promising tools for the effective remediation of PD and other central nervous system disorders. 

KeywordPolymeric Nanoparticles Blood-brain Barrier Drug Delivery Pharmacokinetics Brain Accumulation Parkinsonian Therapy
DOI10.3390/pharmaceutics14081731
Language英語English
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, Tongkai
Affiliation1.Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
2.Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
Recommended Citation
GB/T 7714
Wang, Qun,Ma, Rui,Liu, Piaoxue,et al. Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson's Disease[J]. Pharmaceutics,2022,14(8):1731.
APA Wang, Qun,Ma, Rui,Liu, Piaoxue,Cheng, Guowang,Yang, Qi,Chen, Xiaojia,Wu, Zhenfeng,Yuan, Dongsheng,&Chen, Tongkai.(2022).Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson's Disease.Pharmaceutics,14(8),1731.
MLA Wang, Qun,et al."Efficient Sustained-Release Nanoparticle Delivery System Protects Nigral Neurons in a Toxin Model of Parkinson's Disease".Pharmaceutics 14.8(2022):1731.
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