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Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-based Chemotherapy
Chen, F.; Zhang, F.; Wang, Y.; Peng, J.; Cao, L.; Mei, Q.; Ge, M.; Li, L.; Chen, M.; Dong, W.; Chang, Z.
2022-03-16
Source PublicationFrontiers in Bioengineering and Biotechnology
ISSN2296-4185
Pages860949-860949
AbstractCisplatin-based chemotherapy is dominated in several cancers; however, insufficient therapeutic outcomes and systemic toxicity hamper their clinical applications. Controlled release of cisplatin and reducing inactivation remains an urgent challenge to overcome. Herein, diselenide-bridged mesoporous organosilica nanoparticles (MON) coated with biomimetic cancer cell membrane were tailored for coordination responsive controlled cisplatin delivery and GSH depletion to strengthen Pt-based chemotherapy. Cisplatin-loaded MON (MON-Pt) showed high loading capacity due to robust coordination between selenium and platinum atoms and preventing premature leakage in normal tissue. MON-Pt exhibited a controlled release of activated cisplatin in response to the redox tumor microenvironment. Meanwhile, MON-Pt containing redox-responsive diselenide bonds could efficiently scavenge intracellular inactivation agents, such as GSH, to enhance Pt-based chemotherapy. 4T1 breast cancer cell membranes cloaked MON-Pt (MON-Pt@CM) performed efficient anticancer performance and low in vivo system toxicity due to long blood circulation time and high tumor accumulation benefiting from the tumor targeting and immune-invasion properties of the homologic cancer cell membrane. These results suggest a biomimetic nanocarrier to control release and reduce the inactivation of cisplatin for efficient and safe Pt-based chemotherapy by responding and regulating the tumor microenvironment.
KeywordN
URLView the original
Language英語English
The Source to ArticlePB_Publication
PUB ID63104
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong, W.; Chang, Z.
Recommended Citation
GB/T 7714
Chen, F.,Zhang, F.,Wang, Y.,et al. Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-based Chemotherapy[J]. Frontiers in Bioengineering and Biotechnology,2022:860949-860949.
APA Chen, F.,Zhang, F.,Wang, Y.,Peng, J.,Cao, L.,Mei, Q.,Ge, M.,Li, L.,Chen, M.,Dong, W.,&Chang, Z..(2022).Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-based Chemotherapy.Frontiers in Bioengineering and Biotechnology,860949-860949.
MLA Chen, F.,et al."Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-based Chemotherapy".Frontiers in Bioengineering and Biotechnology (2022):860949-860949.
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