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A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy
Peng, J.; Chen, F.; Liu, Y.; Zhang, F.; Cao, L.; You, Q.; Yang, D.; Chang, Z.; Ge, M.; Li, L.; Wang, Z.; Mei, Q.; Shao, D.; Chen, M.; Dong, W.
2022
Source PublicationTheranostics
ISSN1838-7640
Pages1756-1768
AbstractDesigning a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains a challenge. Here, a near-infrared (NIR) light-driven nanosystem with size and charge dual-transformation for deep tumor penetration is developed. Methods: The core-shell nanotransformer is realized by integrating diselenide-bridged mesoporous organosilica nanoparticles as a reactive oxygen species (ROS)-responsive core with an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer as a thermosensitive shell. After loading doxorubicin (DOX), negatively charged nanomedicine prevents DOX leakage, rendering prolonged blood circulation time and high tumor accumulation. Results: Upon NIR light irradiation, mild photothermal effects facilitate the dissociation of the thermosensitive shell to achieve negative-to-positive charge reversal. Meanwhile, ICG-generated ROS cleave the diselenide bond of the organosilica core, resulting in rapid matrix degradation that produces DOX-containing smaller fragments. Such a light-driven dual-transformable nanomedicine simultaneously promotes deep tumor penetration and implements sufficient chemotherapy, along with evoking robust immunogenic cell death effects in vitro and in vivo. With the combination of a programmed cell death protein-1 (PD-1) checkpoint blockade, the nanotransformer remarkably blocks primary tumor growth and pulmonary metastasis of breast cancer with low systemic toxicity. Conclusions: This study develops a promising strategy to realize high tumor accumulation and deep penetration of light-transformable nanomedicine for efficient and safe chemo-immunotherapy.
Keywordphototherapy light response tumor penetration mesoporous organosilica nanoparticles immunotherapy
URLView the original
Language英語English
The Source to ArticlePB_Publication
PUB ID63092
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, F.; Shao, D.; Dong, W.
Recommended Citation
GB/T 7714
Peng, J.,Chen, F.,Liu, Y.,et al. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy[J]. Theranostics,2022:1756-1768.
APA Peng, J.,Chen, F.,Liu, Y.,Zhang, F.,Cao, L.,You, Q.,Yang, D.,Chang, Z.,Ge, M.,Li, L.,Wang, Z.,Mei, Q.,Shao, D.,Chen, M.,&Dong, W..(2022).A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy.Theranostics,1756-1768.
MLA Peng, J.,et al."A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy".Theranostics (2022):1756-1768.
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