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Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis
Yuan-Fu Ding1,2; Jianwen Wei1; Xingping Quan1; Wenting Gu1; Long Xi1; Ying Zheng1,3; Yonghua Zhao1,3; Jingwei Luo4; Shengke Li1; Greta S.P. Mok2; Ruibing Wang1,3
2022-11-15
Source PublicationCarbohydrate Polymers
ISSN0144-8617
Volume296Pages:119968
Abstract

Psoriasis seriously harms physical and mental health of patients. Hyaluronic acid (HA)-based topical formulation can increase drug concentration in psoriatic skin via CD44-assisted targeting. Herein, we developed a supramolecular medicine composed of curcumin-loaded HA-cucurbit[7]uril (HA-CB[7]@Cur), which could efficiently sequester polyamines (PAs) via host-guest interactions of CB[7] and PAs to suppress RNA-PAs immunocomplex formation. Meanwhile, anti-psoriasis drug Cur could be released from HA-CB[7]@Cur by PAs. With phenotypical disease evaluation, psoriasis area measurements and severity index scoring, and histological characterizations, we demonstrate topical administration of Carbopol gel formulation of HA-CB[7]@Cur on psoriasis-like skin in mice exhibited an enhanced anti-psoriasis activity, in comparison with gel of free Cur or HA-CB[7]. Cytokine expression analysis in psoriatic skin also supported the observed therapeutic outcomes. We provide a novel and effective supramolecular strategy to realize cooperative anti-psoriasis via controlled release of curcumin and PAs sequestration, which can be potentially expanded to treat other PA-involved skin inflammatory diseases.

KeywordCd-44 Targeting Host-guest Interactions Controlled Release Polyamine Sequestration Cooperative Anti-psoriasis
DOI10.1016/j.carbpol.2022.119968
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000843529700002
Scopus ID2-s2.0-85136109711
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorYuan-Fu Ding; Jianwen Wei; Shengke Li; Greta S.P. Mok; Ruibing Wang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
2.Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, University of Macau, Taipa, Macao
3.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao
4.UltraSpec Lab, Victoria, V8P 2N1, BC, Canada
First Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Yuan-Fu Ding,Jianwen Wei,Xingping Quan,et al. Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis[J]. Carbohydrate Polymers,2022,296:119968.
APA Yuan-Fu Ding,Jianwen Wei,Xingping Quan,Wenting Gu,Long Xi,Ying Zheng,Yonghua Zhao,Jingwei Luo,Shengke Li,Greta S.P. Mok,&Ruibing Wang.(2022).Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis.Carbohydrate Polymers,296,119968.
MLA Yuan-Fu Ding,et al."Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis".Carbohydrate Polymers 296(2022):119968.
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