Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury
Zheng, W.
Source Publication中国药理学会表观遗传药理专业委员会. 2021年医药前沿-第六届表观遗传与生物医药研发学术大会
AbstractDepression is a prevalent psychiatric disorder and a leading cause of disability worldwide. Despite a variety of available treatments currently being used in the clinic, a substantial proportion of patients is unresponsive to these treatments, urging the development of more effective therapeutic approaches. Hederagenin (Hed), a triterpenoid saponin extracted from Fructus Akebiae, has several biological activities including anti-apoptosis, anti-hyperlipidemic and anti-inflammatory properties. Over the years, its potential therapeutic effect in depression has also been proposed, but the information is limited and the mechanisms underlying its antidepressant-like effects are unclear. The present study explored the neuroprotective effects and the potential molecular mechanisms of Hederagenin action in corticosterone (CORT)-injured PC12 cells. Obtained results show that Hederagenin protected PC12 cells against CORT-induced damage in a concentration dependent manner. In adittion, Hederagenin prevented the decline of mitochondrial membrane potential, reduced the production of intracellular reactive oxygen species (ROS) and decreased the apoptosis induced by CORT. The protective effect of Hederagenin was reversed by a specific phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and AKT (also known as protein kinase B) inhibitor MK2206, suggesting that the effect of Hederagenin is mediated by the PI3K/AKT pathway. In line with this, western blot analysis results showed that Hederagenin stimulated the phosphorylation of AKT and its downstream target Forkhead box class O3a (FoxO3a) and Glycogen synthase kinase‐3‐beta (GSK3β) in a concentration dependent manner. Taken together, these results indicate that the neuroprotective effect of Hederagenin is likely to occur via stimulation of the PI3K/AKT pathway.
KeywordHederagenin Corticosterone PC12 cells AKT Pathway Depression
The Source to ArticlePB_Publication
PUB ID62205
Document TypeConference paper
Recommended Citation
GB/T 7714
Zheng, W.. Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury[C],2021.
APA Zheng, W..(2021).Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury.中国药理学会表观遗传药理专业委员会. 2021年医药前沿-第六届表观遗传与生物医药研发学术大会.
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