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Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy
Yizhou Jiang1; Limor Rubin, MD2; Tangming Peng1; Linlin Liu1; Xingan Xing1; Philip Lazarovici3; Zheng WH(鄭文華)1
2022
Source PublicationInternational Journal of Biological Sciences
ISSN1449-2288
Volume2022Issue:18Pages:459-472
Abstract
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of
proinflammatory cytokines, also known as cytokine storm, is a severe clinical syndrome known to
develop as a complication of infectious or inflammatory diseases. Clinical evidence suggests that the
occurrence of cytokine storm in severe acute respiratory syndrome secondary to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely associated with the rapid
deterioration and high mortality of severe cases. In this review, we aim to summarize the mechanism of
SARS-CoV-2 infection and the subsequent immunological events related to excessive cytokine
production and inflammatory responses associated with ACE2-AngII signaling. An overview of the
diagnosis and an update on current therapeutic regimens and vaccinations is also provided.
KeywordCytokine Storm Covid-19 Sars-cov-2 Immune Response Cytokines Diagnosis Therapy Vaccination
DOI10.7150/ijbs.59272
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYizhou Jiang
Affiliation1.Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
2.Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
3.School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yizhou Jiang,Limor Rubin, MD,Tangming Peng,et al. Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy[J]. International Journal of Biological Sciences,2022,2022(18):459-472.
APA Yizhou Jiang,Limor Rubin, MD,Tangming Peng,Linlin Liu,Xingan Xing,Philip Lazarovici,&Zheng WH.(2022).Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy.International Journal of Biological Sciences,2022(18),459-472.
MLA Yizhou Jiang,et al."Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy".International Journal of Biological Sciences 2022.18(2022):459-472.
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