UM  > Institute of Chinese Medical Sciences
Residential Collegefalse
Status已發表Published
The role of p53 in the alternation of vascular functions
Chan, Gabriel Hoi Huen1; Chan, Enoch2; Kwok, Carsten Tsun Ka3; Leung, George Pak Heng4; Lee, Simon Ming Yuen5; Seto, Sai Wang3,6,7
2022-09-06
Source PublicationFrontiers in Pharmacology
ISSN1663-9812
Volume13
Abstract

Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endothelial dysfunction, reduced bioavailability of endothelium-derived nitric oxide are usual phenomena observed in patients with cardiovascular diseases. Myriad of studies have been done to investigate to delay the vascular dysfunction or improve the vascular function to prolong the aging process. Tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. Therefore, in recent three decades, p53 has drawn scientists’ attention on its effects in vascular function. Though the role of tumor suppressor gene p53 is still not clear in vascular function, it is found to play regulatory roles and may involve in vascular remodeling, atherosclerosis or pulmonary hypertension. p53 may have a divergent role in endothelial and vascular muscle cells in those conditions. In this review, we describe the different effects of p53 in cardiovascular physiology. Further studies on the effects of endothelial cell-specific p53 deficiency on atherosclerotic plaque formation in common animal models are required before the therapeutic potential can be realized.

KeywordAtherosclerosis Endothelial Dysfunction P53 Vascular Smooth Muscle Cell Vascular Smooth Muscle Migration Vascular Smooth Muscle Proliferation
DOI10.3389/fphar.2022.981152
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000860231000001
Scopus ID2-s2.0-85138436466
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Division of Science, Engineering and Health Studies, College of Professional and Continuing Education, The Hong Kong Polytechnic University, Kowloon, Hong Kong
2.School of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong
3.Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
4.Department of Pharmacology and Pharmacy, The University of Hong Kong, Kowloon, Hong Kong
5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Avenida da Universidade, Macao
6.Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Kowloon, Hong Kong
7.NICM Health Research Institute, Western Sydney University, Penrith, Australia
Recommended Citation
GB/T 7714
Chan, Gabriel Hoi Huen,Chan, Enoch,Kwok, Carsten Tsun Ka,et al. The role of p53 in the alternation of vascular functions[J]. Frontiers in Pharmacology,2022,13.
APA Chan, Gabriel Hoi Huen,Chan, Enoch,Kwok, Carsten Tsun Ka,Leung, George Pak Heng,Lee, Simon Ming Yuen,&Seto, Sai Wang.(2022).The role of p53 in the alternation of vascular functions.Frontiers in Pharmacology,13.
MLA Chan, Gabriel Hoi Huen,et al."The role of p53 in the alternation of vascular functions".Frontiers in Pharmacology 13(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chan, Gabriel Hoi Huen]'s Articles
[Chan, Enoch]'s Articles
[Kwok, Carsten Tsun Ka]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chan, Gabriel Hoi Huen]'s Articles
[Chan, Enoch]'s Articles
[Kwok, Carsten Tsun Ka]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chan, Gabriel Hoi Huen]'s Articles
[Chan, Enoch]'s Articles
[Kwok, Carsten Tsun Ka]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.