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The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish
Zhang, Yaolei1,4,8; Gao, Haoyang1,4; Li, Hanbo1,4; Guo, Jiao1,4; Ouyang, Bingjie1,4; Wang, Meiniang2,4; Xu, Qiwu1,4; Wang, Jiahao1,4; Lv, Meiqi1,4; Guo, Xinyu1,4; Liu, Qun1,4; Wei, Likun5; Ren, Han2,4; Xi, Yang2,4; Guo, Yang1,4; Ren, Bingzhao1,4; Pan, Shanshan1,4; Liu, Chuxin2,4; Ding, Xiaoyan1,4; Xiang, Haitao2,4; Yu, Yingjia1,4; Song, Yue1,4; Meng, Lingfeng1,4; Liu, Shanshan1,4; Wang, Jun1,4; Jiang, Yuan2,6; Shi, Jiahai5; Liu, Shiping2,4; Sabir, Jamal S.M.9; Sabir, Mumdooh J.9; Khan, Muhummadh9; Hajrah, Nahid H.9; Ming-Yuen Lee, Simon3; Xu, Xun2,4; Yang, Huanming2,7; Wang, Jian2,7; Fan, Guangyi1,3,4; Yang, Naibo2,6; Liu, Xin1,2,4
2020-11-20
Source PublicationiScience
ISSN2589-0042
Volume23Issue:11
Abstract

Chondrichthyan (cartilaginous fish) occupies a key phylogenetic position and is important for investigating evolutionary processes of vertebrates. However, limited whole genomes impede our in-depth knowledge of important issues such as chromosome evolution and immunity. Here, we report the chromosome-level genome of white-spotted bamboo shark. Combing it with other shark genomes, we reconstructed 16 ancestral chromosomes of bamboo shark and illustrate a dynamic chromosome rearrangement process. We found that genes on 13 fast-evolving chromosomes can be enriched in immune-related pathways. And two chromosomes contain important genes that can be used to develop single-chain antibodies, which were shown to have high affinity to human disease markers by using enzyme-linked immunosorbent assay. We also found three bone formation-related genes were lost due to chromosome rearrangements. Our study highlights the importance of chromosome rearrangements, providing resources for understanding of cartilaginous fish diversification and potential application of single-chain antibodies.

KeywordBiological Sciences Evolutionary Biology Genetics Genomics Phylogenetics
DOI10.1016/j.isci.2020.101754
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000594412600005
Scopus ID2-s2.0-85097428624
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Citation statistics
Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Affiliation1.BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China
2.BGI-Shenzhen, Shenzhen, 518083, China
3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, Macao, Macao
4.China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China
5.City University of Hongkong, Kowloon, Hong Kong
6.Complete Genomics, Inc., San Jose, 95134, United States
7.James D. Watson Institute of Genome Sciences, Hangzhou, 310058, China
8.Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, 2800, Denmark
9.Department of Biological Sciences, King Abdulaziz University (KAU), Jeddah, 21589, Saudi Arabia
Recommended Citation
GB/T 7714
Zhang, Yaolei,Gao, Haoyang,Li, Hanbo,et al. The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish[J]. iScience,2020,23(11).
APA Zhang, Yaolei.,Gao, Haoyang.,Li, Hanbo.,Guo, Jiao.,Ouyang, Bingjie.,Wang, Meiniang.,Xu, Qiwu.,Wang, Jiahao.,Lv, Meiqi.,Guo, Xinyu.,Liu, Qun.,Wei, Likun.,Ren, Han.,Xi, Yang.,Guo, Yang.,Ren, Bingzhao.,Pan, Shanshan.,Liu, Chuxin.,Ding, Xiaoyan.,...&Liu, Xin.(2020).The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish.iScience,23(11).
MLA Zhang, Yaolei,et al."The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish".iScience 23.11(2020).
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