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Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation
Hao, Wei1; Chen, Zhejie1; Yuan, Qin1; Ma, Meiling1; Gao, Caifang1; Zhou, Yangyang1; Zhou, Hefeng2; Wu, Xu3; Wu, Dingtao4; Farag, Mohamed A.5; Wang, Shengpeng1; Wang, Yitao1
2022-10-31
Source PublicationInternational Journal of Biological Macromolecules
ISSN0141-8130
Volume219Pages:730-739
Abstract

Ulcerative colitis (UC) is an autoimmune disease afflicting an increasing number of patients and increasing demands towards the development of efficacious and safe drugs. Recently, with increasing interest in alternative medicines, natural resources have become a hotspot for drug discovery against UC. In addition to being consumed as a food and spice, ginger is also widely used as a well-recognized gastrointestinal herbal medicine. With a long history in the treatment of digestive disorders, the potential of ginger in alleviating UC has been documented in several experimental models and clinical trials. However, as a major active constituent of ginger, ginger polysaccharides (GP) and its effect on UC has yet to be reported. In this study, GP was firstly separated and characterized. In a dextran sulfate sodium (DSS)-induced colitis mouse model, GP alleviated UC symptoms by inhibiting pro-inflammatory cytokines levels to regulate intestinal inflammation, repairing the intestinal barrier as indicated by occludin-1 and ZO-1, as well as regulating gut microbiota. Taking these results together, we believe GP could be an innovative option in developing functional foods or therapeutic agents for UC management.

KeywordGinger Polysaccharides Ulcerative Colitis
DOI10.1016/j.ijbiomac.2022.08.032
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000861260600006
Scopus ID2-s2.0-85135857013
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China
2.Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, China
3.Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
4.Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu, China
5.Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Kasr el Aini St., 11562, Egypt
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Hao, Wei,Chen, Zhejie,Yuan, Qin,et al. Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation[J]. International Journal of Biological Macromolecules,2022,219:730-739.
APA Hao, Wei,Chen, Zhejie,Yuan, Qin,Ma, Meiling,Gao, Caifang,Zhou, Yangyang,Zhou, Hefeng,Wu, Xu,Wu, Dingtao,Farag, Mohamed A.,Wang, Shengpeng,&Wang, Yitao.(2022).Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation.International Journal of Biological Macromolecules,219,730-739.
MLA Hao, Wei,et al."Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation".International Journal of Biological Macromolecules 219(2022):730-739.
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