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High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer
Wang, Qingshui1,2,3; Weng, Shuyun3; Sun, Yuqin4; Lin, Youyu3; Zhong, Wenting3; Kwok, Hang Fai2,5,6; Lin, Yao1,7
2022-10-01
Source PublicationBiology
ISSN2079-7737
Volume11Issue:10
Abstract

Gastric cancer (GC) is a common upper gastrointestinal tumor. Death-associated protein kinase (DAPK1) was found to participate in the development of various malignant tumors. However, there are few reports on DAPK1 in gastric cancer. In this study, the TCGA and GEO datasets were used to explore the expression and role of DAPK1 in gastric cancer. The functions of DAPK1 in gastric cancer were determined by proliferation, migration and invasion assays. In addition, genes co-expressed with DAPK1 in gastric cancer were estimated through the WGCNA and correlation analysis. A DAPK1-related gene prognostic model was constructed using the Cox regression and lasso analyses. The expression of DAPK1 was significantly up-regulated in gastric cancer tissues. Kaplan–Meier analysis showed that low expression of DAPK1 was a favorable prognostic factor of overall survival and disease-free survival for gastric cancer patients. Functional experiments demonstrated that DAPK1 can promote the migration and invasion of gastric cancer cells. WGCNA, correlation analysis, Cox regression, and lasso analyses were applied to construct the DAPK1-related prognostic model. The prognostic value of this prognostic model of DAPK1-related genes was further successfully validated in an independent database. Our results indicated that DAPK1 can promote gastric cancer cell migration and invasion and established four DAPK1-related signature genes for gastric cancer that could independently predict the survival of GC patients.

KeywordDapk1 Gastric Cancer Prognosis Prognostic Signature Suppressor
DOI10.3390/biology11101488
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000872168500001
Scopus ID2-s2.0-85140399668
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Fujian Univ Tradit Chinese Med, Cent Lab, Innovat & Transformat Ctr,Affiliated Hosp 2, Fujian Macao Sci & Technol Cooperat Base Tradit C, Fuzhou 350001, Peoples R China
2.Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Avenida de Universidade, Macao
3.Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350001, China
4.Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, China
5.MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Avenida de Universidade, Macao
6.Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao
7.Collaborative Innovation Center for Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, 350001, China
First Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Wang, Qingshui,Weng, Shuyun,Sun, Yuqin,et al. High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer[J]. Biology,2022,11(10).
APA Wang, Qingshui,Weng, Shuyun,Sun, Yuqin,Lin, Youyu,Zhong, Wenting,Kwok, Hang Fai,&Lin, Yao.(2022).High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer.Biology,11(10).
MLA Wang, Qingshui,et al."High DAPK1 Expression Promotes Tumor Metastasis of Gastric Cancer".Biology 11.10(2022).
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