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Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications
Tan, Dechao; Tseng, Hisa Hui Ling; Zhong, Zhangfeng; Wang, Shengpeng; Vong, Chi Teng; Wang, Yitao
2022-10-01
Source PublicationInternational Journal of Molecular Sciences
ISSN1661-6596
Volume23Issue:19
Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, which is characterized by hyperglycemia, chronic insulin resistance, progressive decline in β-cell function, and defect in insulin secretion. It has become one of the leading causes of death worldwide. At present, there is no cure for T2DM, but it can be treated, and blood glucose levels can be controlled. It has been reported that diabetic patients may suffer from the adverse effects of conventional medicine. Therefore, alternative therapy, such as traditional Chinese medicine (TCM), can be used to manage and treat diabetes. In this review, glycyrrhizic acid (GL) and its derivatives are suggested to be promising candidates for the treatment of T2DM and its complications. It is the principal bioactive constituent in licorice, one type of TCM. This review comprehensively summarized the therapeutic effects and related mechanisms of GL and its derivatives in managing blood glucose levels and treating T2DM and its complications. In addition, it also discusses existing clinical trials and highlights the research gap in clinical research. In summary, this review can provide a further understanding of GL and its derivatives in T2DM as well as its complications and recent progress in the development of potential drugs targeting T2DM.

KeywordAmmonium Glycyrrhizinate Diabetic Complications Diammonium Glycyrrhizinate Glucose Tolerance Glycyrrhetinic Acid Glycyrrhizic Acid Insulin Resistance Type 2 Diabetes Mellitus
DOI10.3390/ijms231910988
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000867710300001
Scopus ID2-s2.0-85139981216
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationMacau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tan, Dechao,Tseng, Hisa Hui Ling,Zhong, Zhangfeng,et al. Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications[J]. International Journal of Molecular Sciences,2022,23(19).
APA Tan, Dechao,Tseng, Hisa Hui Ling,Zhong, Zhangfeng,Wang, Shengpeng,Vong, Chi Teng,&Wang, Yitao.(2022).Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications.International Journal of Molecular Sciences,23(19).
MLA Tan, Dechao,et al."Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications".International Journal of Molecular Sciences 23.19(2022).
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