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Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies
Wang, Jing1,2; Luo, Zhijie3; Lin, Lizhu3; Sui, Xinbing4; Yu, Lili1; Xu, Cong1; Zhang, Ruonan1; Zhao, Ziming1; Zhu, Qianru1; An, Bo1; Wang, Qiao1; Chen, Bi1; Leung, Elaine Lai Han5; Wu, Qibiao1,6,7
Source PublicationCancers

Tumor metastasis occurs in lung cancer, resulting in tumor progression and therapy failure. Anoikis is a mechanism of apoptosis that combats tumor metastasis; it inhibits the escape of tumor cells from the native extracellular matrix to other organs. Deciphering the regulators and mechanisms of anoikis in cancer metastasis is urgently needed to treat lung cancer. Several natural and synthetic products exhibit the pro-anoikis potential in lung cancer cells and in vivo models. These products include artonin E, imperatorin, oroxylin A, lupalbigenin, sulforaphane, renieramycin M, avicequinone B, and carbenoxolone. This review summarizes the current understanding of the molecular mechanisms of anoikis regulation and relevant regulators involved in lung cancer metastasis and discusses the therapeutic potential of targeting anoikis in the treatment of lung cancer metastasis.

KeywordAnoikis Apoptosis Lung Cancer Molecular Mechanism Therapy Neoplasm Metastasis
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Indexed BySCIE
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000866687700001
Scopus ID2-s2.0-85139820668
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Document TypeJournal article
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao
2.Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China
3.The First Clinical Medical College, The First Hospital Affiliated, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China
4.School of Pharmacy, Department of Medical Oncology, Hangzhou Normal University, Hangzhou, 311121, China
5.Cancer Center, Faculty of Health Science, MOE Frontiers Science Center for Precision Oncology, University of Macau, 999078, Macao
6.Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong University of Technology, Guangzhou, 510006, China
7.Zhuhai MUST Science and Technology Research Institute, Zhuhai, 519031, China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Jing,Luo, Zhijie,Lin, Lizhu,et al. Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies[J]. Cancers,2022,14(19).
APA Wang, Jing,Luo, Zhijie,Lin, Lizhu,Sui, Xinbing,Yu, Lili,Xu, Cong,Zhang, Ruonan,Zhao, Ziming,Zhu, Qianru,An, Bo,Wang, Qiao,Chen, Bi,Leung, Elaine Lai Han,&Wu, Qibiao.(2022).Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies.Cancers,14(19).
MLA Wang, Jing,et al."Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies".Cancers 14.19(2022).
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