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Alternative TitleReview of classical prescriptions in treatment of ulcerative colitis
Ai, Yong Jian1; He, Meng Qi1; Wang, Yi Tao2; Liang, Qiong Lin1
Source Publication中国中药杂志



Other Abstract

Ulcerative colitis (UC) is a continuous inflammatory bowel disease with the main clinical manifestations of abdominal pain, diarrhea, and mucous bloody stools, mainly attacking the colorectal mucosa and submucosa. It is characterized by high recurrence rate, difficult cure, and clustering and regional occurrence. Chinese medicinal prescriptions for the treatment of UC have good therapeutic effect, multi-target regulation, slight toxicity, and no obvious side effects. In particular, the classical prescriptions highlight the characteristics and advantages of traditional Chinese medicine theory and have attracted much attention in recent years. To enable researchers to timely and comprehensively understand the classical prescriptions in the treatment of UC, we reviewed the studies about the pharmacodynamic material basis, quality control, action mechanism, and clinical application of relevant classical prescriptions. We first introduced the latest research progress in the active components such as alkaloids, polysaccharides, saponins, and flavonoids in relevant classical prescriptions. Then, we reviewed the latest research achievements on the quality control of classical prescriptions for the treatment of UC by gas chromatography, liquid chromatography, mass spectrometry, liquid chromatography-mass spectrometry and the like. Further, we summarized the research advances in the mechanisms of relevant prescriptions in the treatment of UC based on network pharmacology, molecular docking, integrated pharmacology platform, and animal experiments. Finally, we generalized the clinical application of the classical prescriptions for clearing heat and removing dampness, mildly regulating cold and heat, soothing liver and regulating spleen, strengthening spleen and invigorating Qi, and tonifying spleen and stomach. By systematic summary of the research progress in relevant classical prescriptions, we hope to promote the application and development of such prescriptions in UC treatment.

Keyword经典方药 溃疡性结肠炎 物质基础 质量控制 作用机制 临床应用
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Indexed By核心期刊 ; CSCD
Scopus ID2-s2.0-85142513956
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Traditional Chinese Medicine-X, State Administration of Traditional Chinese Medicine Third-level Laboratory of Traditional Chinese Medicine Chemistry, Chinese Medicine Modernization Research Center, Tsinghua University, Beijing, 100084, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, Macao
Recommended Citation
GB/T 7714
Ai, Yong Jian,He, Meng Qi,Wang, Yi Tao,等. 经典方药治疗溃疡性结肠炎的研究进展[J]. 中国中药杂志,2022,47(21):5797-5805.
APA Ai, Yong Jian,He, Meng Qi,Wang, Yi Tao,&Liang, Qiong Lin.(2022).经典方药治疗溃疡性结肠炎的研究进展.中国中药杂志,47(21),5797-5805.
MLA Ai, Yong Jian,et al."经典方药治疗溃疡性结肠炎的研究进展".中国中药杂志 47.21(2022):5797-5805.
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