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Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends
Song, Sheng Lei1,2,3; Li, Bo1,4; Carvalho, Mariana R.5,6; Wang, Hui Jin1,2,3; Mao, De Li1,2,3; Wei, Ji Tao1,4; Chen, Wei1; Weng, Zhi Hui7,8; Chen, Yang Chao9; Deng, Chu Xia7,8; Reis, Rui L.5,6; Oliveira, Joaquim M.5,6; He, Yu Long1,2,3; Yan, Le Ping1,4; Zhang, Chang Hua1,2
2022-11-01
Source PublicationPharmacology and Therapeutics
ISSN0163-7258
Volume239
Abstract

Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research. However, their ability to enable cancer precision medicine is limited. Cell culture models cannot retain the genetic and phenotypic heterogeneity of tumors and lack tumor microenvironment (TME). Patient-derived xenograft mouse models are not suitable for immune-oncology research. While humanized mouse models are time- and cost-consuming. Suitable preclinical models, which can facilitate the understanding of mechanisms of tumor progression and develop new therapeutic strategies, are in high demand. This review article summarizes the recent progress on the establishment of TME by using tumor organoid models and microfluidic systems. The main challenges regarding the translation of organoid models from bench to bedside are discussed. The integration of organoids and a microfluidic platform is the emerging trend in drug screening and precision medicine. A future prospective on this field is also provided.

KeywordCancer-on-a-chip Digestive System Cancer In Vitro 3d Models Organoids Tumor Microenvironment
DOI10.1016/j.pharmthera.2022.108276
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000864081700002
Scopus ID2-s2.0-85137296517
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FWCI0.0
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China
2.Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China
3.Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China
4.Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China
5.3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Portugal
6.ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
7.Cancer Center Faculty of Health Sciences, University of Macau, Macau, 999078, Macao
8.Center for Precision Medicine Research and Training Faculty of Health Sciences, University of Macau, Macau, 999078, Macao
9.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Shatin NT, Hong Kong
Recommended Citation
GB/T 7714
Song, Sheng Lei,Li, Bo,Carvalho, Mariana R.,et al. Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends[J]. Pharmacology and Therapeutics,2022,239.
APA Song, Sheng Lei,Li, Bo,Carvalho, Mariana R.,Wang, Hui Jin,Mao, De Li,Wei, Ji Tao,Chen, Wei,Weng, Zhi Hui,Chen, Yang Chao,Deng, Chu Xia,Reis, Rui L.,Oliveira, Joaquim M.,He, Yu Long,Yan, Le Ping,&Zhang, Chang Hua.(2022).Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends.Pharmacology and Therapeutics,239.
MLA Song, Sheng Lei,et al."Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends".Pharmacology and Therapeutics 239(2022).
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