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Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules
Dong, Qian1; Wang, Xuewei1; Hu, Xiaoxiao1; Xiao, Langqiu1; Zhang, Liang1; Song, Lijuan1; Xu, Minglu1; Zou, Yuxiu1; Chen, Long2; Chen, Zhuo1; Tan, Weihong1,3
2018-01
Source PublicationAngewandte Chemie - International Edition
ISSN15213773 14337851
Volume57Issue:1Pages:177-181
Abstract

Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene–aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π–π interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.

KeywordAspirin Graphitic Nanocapsules Inflammation Photothermal Therapy Prodrugs
DOI10.1002/anie.201709648
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS IDWOS:000418798600016
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Cited Times [WOS]:121   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF COMPUTER AND INFORMATION SCIENCE
Corresponding AuthorChen, Zhuo
Affiliation1.Hunan University
2.University of Macau
3.University of Florida
Recommended Citation
GB/T 7714
Dong, Qian,Wang, Xuewei,Hu, Xiaoxiao,et al. Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules[J]. Angewandte Chemie - International Edition,2018,57(1):177-181.
APA Dong, Qian,Wang, Xuewei,Hu, Xiaoxiao,Xiao, Langqiu,Zhang, Liang,Song, Lijuan,Xu, Minglu,Zou, Yuxiu,Chen, Long,Chen, Zhuo,&Tan, Weihong.(2018).Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules.Angewandte Chemie - International Edition,57(1),177-181.
MLA Dong, Qian,et al."Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules".Angewandte Chemie - International Edition 57.1(2018):177-181.
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