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Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine
Liu, Tzu-Ming1,2,3; Conde, Joao4,5; Lipinski, Tomasz6,7; Bednarkiewicz, Artur7,8; Huang, Chih-Chia9

Light-based diagnostics and therapy have become indispensable tools in the field of cancer nanomedicine. Various optical imaging modalities with tomographic capability have been developed to visualize cellular and organismic distributions of molecules. Microscopic pharmacokinetics and the tumor-targeting efficacy of nanoscale effectors can now be precisely evaluated. Moreover, phototherapy using intense laser light has been widely used for treating cancers. Using light-active nanoscale effectors, photothermal and photodynamic therapies on superficial tumors can be achieved with low-illumination lasers. Consequently, for the next generation of photo-medical techniques, the use of near infrared (NIR) excitation sources on NIR-activatable nanoparticles may offer deeper light penetration owing to less extensive scattering and absorption by endogenous chromophores in the NIR spectral region. Therefore, treatments and biodetection within higher tissue volumes and with less side effects (e.g. overheating) may be successfully implemented. This comprehensive review covers the state-of-the-art technologies on (a) advanced laser light sources appropriate for deep tissue theranostics, (b) types of laser interactions with pureNIR and NIR-upconverting nanomaterials, (c) current development of NIR and multiphoton nanoparticles, (d) application fields of NIR nanomaterials in cancer theranostics, and (e) nanotoxicology of NIR nanoscale effectors for cancer treatment.

KeywordNir Nanoparticles Up-conversion Multiphoton Photo-therapy Imaging Cancer Theranostics
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Indexed BySCIE
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000402528500003
The Source to ArticleWOS
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLiu, Tzu-Ming; Conde, Joao; Huang, Chih-Chia
Affiliation1.Faculty of Health Sciences, University of Macau, Macao
2.Institute of Biomedical Engineering, National Taiwan University, Taiwan
3.Molecular Imaging Center, National Taiwan University, Taiwan
4.Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, Cambridge,MA, USA
5.School of Engineering and Materials Science, Queen Mary University of London, London, UK
6.Institute of Immunology and Experimental Therapy, PAS, Wrocław, Poland
7.Wrocław Research Centre EIT+, Wrocław, Poland
8.Institute of Low Temp & Structure Research, PAS, Wrocław, Poland
9.Department of Photonics, Center for Micro/Nano Science and Technology, Advanced Optoelectronic Technology Center, National Cheng Kung University, Taiwan
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Liu, Tzu-Ming,Conde, Joao,Lipinski, Tomasz,et al. Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine[J]. PROGRESS IN MATERIALS SCIENCE,2017,88:89-135.
APA Liu, Tzu-Ming,Conde, Joao,Lipinski, Tomasz,Bednarkiewicz, Artur,&Huang, Chih-Chia.(2017).Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine.PROGRESS IN MATERIALS SCIENCE,88,89-135.
MLA Liu, Tzu-Ming,et al."Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine".PROGRESS IN MATERIALS SCIENCE 88(2017):89-135.
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