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Fabrication of highly modulable fibrous 3D extracellular microenvironments
Zhang X.1; Han F.2; Syed A.1; Bukhari E.M.1; Siang B.C.J.1; Yang S.1; Zhou B.3; Wen W.-J.3; Jiang D.2
Source PublicationBiomedical Microdevices
ISSN15728781 13872176
AbstractThree-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.
Keyword3D cell culture 3D scaffolds Electrospinning Fibrous scaffolds PDMS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.King Abdullah University of Science and Technology
2.Nanjing University
3.Hong Kong University of Science and Technology
Recommended Citation
GB/T 7714
Zhang X.,Han F.,Syed A.,et al. Fabrication of highly modulable fibrous 3D extracellular microenvironments[J]. Biomedical Microdevices,2017,19(3).
APA Zhang X.,Han F.,Syed A.,Bukhari E.M.,Siang B.C.J.,Yang S.,Zhou B.,Wen W.-J.,&Jiang D..(2017).Fabrication of highly modulable fibrous 3D extracellular microenvironments.Biomedical Microdevices,19(3).
MLA Zhang X.,et al."Fabrication of highly modulable fibrous 3D extracellular microenvironments".Biomedical Microdevices 19.3(2017).
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