Affiliated with RCfalse
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance
Ma, Xiaojun; Lin, Ligen; Yue, Jing; Wu, Chia-Shan; Guo, Cathy A.; Wang, Ruitao; Yu, Kai-Jiang; Devaraj, Sridevi; Murano, Peter; Chen, Zheng; Sun, Yuxiang
AbstractHigh fructose corn syrup (HFCS) is widely used as sweetener in processed foods and soft drinks in the United States, largely substituting sucrose (SUC). The orexigenic hormone ghrelin promotes obesity and insulin resistance; ghrelin responds differently to HFCS and SUC ingestion. Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. To mimic soft drinks, 10-week-old male wild-type (WT) and ghrelin knockout (Ghrelin(-/-)) mice were subjected to ad lib. regular chow diet supplemented with either water (RD), 8% HFCS (HFCS), or 10% sucrose (SUC). We found that SUC-feeding induced more robust increases in body weight and body fat than HFCS-feeding. Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions.
Keywordghrelin HFCS sucrose fructose glucose adiposity insulin resistance adipose tissue inflammation
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000404581500199
PublisherMDPI AG
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Ma, Xiaojun,Lin, Ligen,Yue, Jing,et al. Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(6).
APA Ma, Xiaojun,Lin, Ligen,Yue, Jing,Wu, Chia-Shan,Guo, Cathy A.,Wang, Ruitao,Yu, Kai-Jiang,Devaraj, Sridevi,Murano, Peter,Chen, Zheng,&Sun, Yuxiang.(2017).Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(6).
MLA Ma, Xiaojun,et al."Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.6(2017).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ma, Xiaojun]'s Articles
[Lin, Ligen]'s Articles
[Yue, Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ma, Xiaojun]'s Articles
[Lin, Ligen]'s Articles
[Yue, Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ma, Xiaojun]'s Articles
[Lin, Ligen]'s Articles
[Yue, Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.