This study evaluated the reutilization of waste materials (scrap tires, sewage sludge, and woodchips) to remove volatile organic compounds (VOCs) benzene/toluene/ethylbenzene/xylenes/trichloroethylene/cis-1,2-dichloroethylene (BTEX/TCE/cis-DCE), plasticizer di(2-ethylhexyl) phthalate (DEHP), and pharmaceutically active compound carbamazepine from artificially contaminated water. Different hybrid removal processes were developed: (1) 300 mg/L BTEX+20 mg/LTCE+10 mg/L cis-DCE+ tires+Pseudomonas sp.; (2) 250 mg/L toluene+sewage sludge biochar+Pseudomonas sp.; (3) 100 mg/L DEHP+tires+ Acinetobacter sp.; and (4) 20 mg/L carbamazepine+wood chips+Phanerochaete chrysosporium. For the hybrid process (1), the removal of xylenes, TCE, and cis-DCE was enhanced, resulted from the contribution of both physical adsorption and biological immobilization removal. The hybrid process (2) was also superior for the removal of DEHP and required a shorter time (2 days) for the bioremoval. For the process (3), the biochar promoted the microbial immobilization on its surface and substantially enhanced/speedup the bioremoval of toluene. The fungal immobilization on wood chips in the hybrid process (4) also improved the carbamazepine removal considerably (removal efficiencies of 61.3±0.6%) compared to the suspended system without wood chips (removal efficiencies of 34.4±1.8%). These hybrid processes would not only be promising for the bioremediation of environmentally concerned contaminants but also reutilize waste materials as sorbents without any further treatment.