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A Dual-Head Multi-Pinhole Collimator Design for Stationary Clinical Myocardial Perfusion SPECT Imaging
Pengyu Yan1; Greta S. P. Mok1; Chin-Hong Si1; Benjamin M. W. Tsui2
Publication PlaceUSA

Previously we designed a dual-purpose multi-pinhole (MPH) collimator for improved clinical myocardial perfusion imaging (MPI) with extra capability of small animal imaging for a clinical gamma camera. However, the standard configuration for current clinical MPI is L-mode with two detectors ~90⁰ apart. This study aims to design a dual-head L-mode MPH collimator for potential stationary MPI based on a clinical SPECT/CT scanner. Two stationary L-mode configurations, L-mode-I/II, were proposed based on the work of Rittenbach et al. where the long axis of the left ventricle was perpendicular to either camera. With the pre-defined pinhole pattern with minimal projection truncation and <20% multiplexing, maximum packing density and detector usage, the optimized MPH collimator parameters including pinhole number, radius-of-rotation, collimator length, aperture size and acceptance angle were determined by maximizing the sensitivity based on the pre-determined field-of-view of 20 cm and target resolution of 1 cm, considering the physical constraints of L-mode-I/II. Analytical simulations using the 4D extended cardiac-torso phantom (XCAT) were performed for 4 selected MPH designs with superior sensitivity results. Noise-free and noisy projections were generated and reconstructed using 3D MPH OS-EM algorithm. Reconstructed images were evaluated by visual assessment, normalized-mean-square-error (NMSE) and normalized standard deviation (NSD). L-mode-II generally showed less NMSE as compared to L-mode-I. For L-mode-I, 11-pinhole had the best NMSE-NSD trade-off while for L-mode-II, 18-pinhole had the best trade-off. We concluded that stationary MPI acquisition by using a dual-head MPH collimator is feasible and has the potential for dynamic MPI.

Conference PlaceSeoul, South Korea
Conference Date27 Oct.-2 Nov. 2013
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Document TypeConference proceedings
CollectionFaculty of Science and Technology
Affiliation1.the Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, People’s Republic of China
2.the Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, USA
First Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Pengyu Yan,Greta S. P. Mok,Chin-Hong Si,et al. A Dual-Head Multi-Pinhole Collimator Design for Stationary Clinical Myocardial Perfusion SPECT Imaging[C].USA:IEEE,2014.
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