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FOXO Signaling Pathways as Therapeutic Targets in Cancer
Farhan, Mohd; Wang, Haitao; Gaur, Uma; Little, Peter J.; Xu, Jiangping; Zheng, Wenhua
2017
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume13Issue:7Pages:815-827
Abstract

Many transcription factors play a key role in cellular differentiation and the delineation of cell phenotype. Transcription factors are regulated by phosphorylation, ubiquitination, acetylation/deacetylation and interactions between two or more proteins controlling multiple signaling pathways. These pathways regulate different physiological processes and pathological events, such as cancer and other diseases. The Forkhead box O (FOXO) is one subfamily of the fork head transcription factor family with important roles in cell fate decisions and this subfamily is also suggested to play a pivotal functional role as a tumor suppressor in a wide range of cancers. During apoptosis, FOXOs are involved in mitochondria-dependent and -independent processes triggering the expression of death receptor ligands like Fas ligand, TNF apoptosis ligand and Bcl-X-L, bNIP3, Bim from Bcl-2 family members. Different types of growth factors like insulin play a vital role in the regulation of FOXOs. The most important pathway interacting with FOXO in different types of cancers is the PI3K/AKT pathway. Some other important pathways such as the Ras-MEK-ERK, IKK and AMPK pathways are also associated with FOXOs in tumorigenesis. Therapeutically targeting the FOXO signaling pathway(s) could lead to the discovery and development of efficacious agents against some cancers, but this requires an enhanced understanding and knowledge of FOXO transcription factors and their regulation and functioning. This review focused on the current understanding of cell biology of FOXO transcription factors which relates to their potential role as targets for the treatment and prevention of human cancers. We also discuss drugs which are currently being used for cancer treatment along with their target pathways and also point out some potential drawbacks of those drugs, which further signifies the need for development of new drug strategies in the field of cancer treatment.

KeywordApoptosis Nuclear Translocation Foxo Cell Proliferation Anticancer Drugs Transcription Factors
DOI10.7150/ijbs.20052
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000408370300001
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
Scopus ID2-s2.0-85025146523
Fulltext Access
Citation statistics
Cited Times [WOS]:206   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Recommended Citation
GB/T 7714
Farhan, Mohd,Wang, Haitao,Gaur, Uma,et al. FOXO Signaling Pathways as Therapeutic Targets in Cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(7):815-827.
APA Farhan, Mohd,Wang, Haitao,Gaur, Uma,Little, Peter J.,Xu, Jiangping,&Zheng, Wenhua.(2017).FOXO Signaling Pathways as Therapeutic Targets in Cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(7),815-827.
MLA Farhan, Mohd,et al."FOXO Signaling Pathways as Therapeutic Targets in Cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.7(2017):815-827.
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