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Complexity Change in Cardiovascular Disease
Chen, Chang1; Jin, Yu1; Lo, Iek Long2; Zhao, Hansen3; Sun, Baoqing4; Zhao, Qi1; Zheng, Jun1; Zhang, Xiaohua Douglas1

With the fast development of wearable medical device in recent years, it becomes critical to conduct research on continuously measured physiological signals. Entropy is a key metric for quantifying the irregularity and/or complexity contained in human physiological signals. In this review, we focus on exploring how entropy changes in various physiological signals in cardiovascular diseases. Our review concludes that the direction of entropy change relies on the physiological signals under investigation. For heart rate variability and pulse index, the entropy of a healthy person is higher than that of a patient with cardiovascular diseases. For diastolic period variability and diastolic heart sound, the direction of entropy change is reversed. Our conclusion should not only give valuable guidance for further research on the application of entropy in cardiovascular diseases but also provide a foundation for using entropy to analyze the irregularity and/or complexity of physiological signals measured by wearable medical device.

KeywordEntropy Physiological Signal Cardiovascular Disease Irregularity Complexity
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Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000414256800003
The Source to ArticleWOS
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhang, Xiaohua Douglas
Affiliation1.Univ Macau, Fac Hlth Sci, Taipa, Macao, Peoples R China
2.Ctr Hosp Conde Sao Januario, Dept Geriatr, Macau, Peoples R China
3.Capital Med Univ, Beijing Hosp Chinese Med, Dept Cardiovasc Dis, Beijing, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chen, Chang,Jin, Yu,Lo, Iek Long,et al. Complexity Change in Cardiovascular Disease[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(10):1320-1328.
APA Chen, Chang,Jin, Yu,Lo, Iek Long,Zhao, Hansen,Sun, Baoqing,Zhao, Qi,Zheng, Jun,&Zhang, Xiaohua Douglas.(2017).Complexity Change in Cardiovascular Disease.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(10),1320-1328.
MLA Chen, Chang,et al."Complexity Change in Cardiovascular Disease".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.10(2017):1320-1328.
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