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Emerging roles of SIRT1 in fatty liver diseases
Ding, Ren-Bo; Bao, Jiaolin; Deng, Chu-Xia

Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol consumption and/or other metabolic disorder causes, lead to serious medical concerns worldwide in recent years. It has been demonstrated that metabolic homeostasis disruption is most likely to be responsible for this global epidemic. Sirtuins are a group of conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone and/or protein deacetylases belonging to the silent information regulator 2 (Sir2) family. Among seven mammalian sirtuins, sirtuin 1 (SIRT 1) is the most extensively studied one and is involved in both alcoholic and nonalcoholic fatty liver diseases. SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, controlling hepatic oxidative stress and mediating hepatic inflammation through deacetylating some transcriptional regulators against the progression of fatty liver diseases. Here we summarize the latest advances of the biological roles of SIRT1 in regulating lipid metabolism, oxidative stress and inflammation in the liver, and discuss the potential of SIRT1 as a therapeutic target for treating alcoholic and nonalcoholic fatty liver diseases.

KeywordFatty Liver Diseases Lipogenesis Fatty Acid Beta-oxidation Oxidative Stress Inflammation
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000408370300004
The Source to ArticleWOS
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Cited Times [WOS]:101   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDeng, Chu-Xia
AffiliationCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
First Author AffilicationCancer Centre
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Ding, Ren-Bo,Bao, Jiaolin,Deng, Chu-Xia. Emerging roles of SIRT1 in fatty liver diseases[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(7):852-867.
APA Ding, Ren-Bo,Bao, Jiaolin,&Deng, Chu-Xia.(2017).Emerging roles of SIRT1 in fatty liver diseases.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(7),852-867.
MLA Ding, Ren-Bo,et al."Emerging roles of SIRT1 in fatty liver diseases".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.7(2017):852-867.
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