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Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis
Leung, CH1; Wu, KJ1; Li, GD1; Wu, C2; Ko, CG2; Ma, DL2
2019-08
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume117Pages:78-83
Abstract

Circulating tumor cells (CTCs) are an important biomarker for various types of cancers. As CTCs are extremely rare in the bloodstream, the accurate analysis and efficient separation of CTCs is a challenging task. In order to develop new diagnostic approaches for cancer research, understanding the functional characteristics of biomolecules at the single-molecule level in individual cancer cells is required. Meanwhile, microfluidic platforms have emerged as a promising technology for analyzing single molecules and single cells. In this review, we discuss some label-free techniques for biomolecule detection and highlight some reports that have employed combined label-free techniques with microfluidics for individual molecule or cancer cell analysis. Finally, we offer our perspective of the integration of label-free techniques with microfluidic technology on future applications.

KeywordNucleic-acid Analysis Microfluidics Label-free Circulating Tumor Cells Protein Analysis
DOI10.1016/j.trac.2019.06.003
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000482209800009
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung, CH; Ma, DL
Affiliation1.University of MacauInst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Zhuhai, Macao, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Leung, CH,Wu, KJ,Li, GD,et al. Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,117:78-83.
APA Leung, CH,Wu, KJ,Li, GD,Wu, C,Ko, CG,&Ma, DL.(2019).Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,117,78-83.
MLA Leung, CH,et al."Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 117(2019):78-83.
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