Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression
Arianna Di Lorenzo1; Anatoly P. Sobolev2; Seyed Fazel Nabavi3; Antoni Sureda4; Akbar Hajizadeh Moghaddam5; Sedigheh Khanjani6; Carmen Di Giovanni10; Jianbo Xiao7; Samira Shirooie8; Arold Jorel Tsetegho Sokeng1; Alessandra Baldi1; Luisa Mannina2,9; Seyed Mohammad Nabavi3; Maria Daglia1
Conference Name1st International Conference on Natural Toxicology and Pharmacology (ICNTP)
Conference Date2019-8
Conference PlaceGuangzhou, PEOPLES R CHINA

Mood disorders occur in 30% of stroke patients, and of these post-stroke depression (PSD) is the most significant. This study aimed to evaluate the antidepressive-like effects and in vivo antioxidant activity of a chemically characterized maqui berry (Aristotelia chilensis (Molina) Stuntz) extract obtained from an optimized extraction method, on a murine PSD model. The extraction process was optimized to maximize anthocyanin content, and the phytochemical profile of the extract was evaluated using a multi-methodological approach including a liquid chromatographic method coupled with mass spectrometry and nuclear magnetic resonance spectroscopy. The antidepressive-like activity was investigated through despair swimming and tail suspension tests. The in vivo antioxidant activity was evaluated in mouse brain tissue by measuring the activity of antioxidant enzymes and lipid peroxidation products. A number of compounds have been first identified in maqui berry here, including malvidin-glucoside, GABA, choline and trigonelline. Moreover, the results showed that the antidepressive-like activity exerted by the extract, which was found to restore normal mouse behavior in both despair swimming and tail suspension tests, could be linked to its antioxidant activity, leading to the conclusion that maqui berries might be useful for supporting pharmacological therapy of PSD by modulating oxidative stress.

KeywordChemical Characterization In Vivo Antioxidant Activity Maqui Berry Extract Murine Model System Post-stroke Depression
Indexed BySCI
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000472686200041
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionUniversity of Macau
Affiliation1.Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy
2.stituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica“Annalaura Segre”, CNR, 00015, Monterotondo (Rome), Italy
3.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box, 19395-5487, Tehran, 19395-5487, Iran
4.Grup de Nutrició Comunitària I Estrès Oxidatiu and CIBEROBN (Physiopathology of Obesity and Nutrition), Universitat de les Illes Balears, Palma de Mallorca, E-07122,Spain
5.Department of Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran
6.Department of Physiology, Faculty of Biological Sciences, Shahid Behshti University, P.O. Box, 19615-1178, Tehran, 19615-1178, Iran
7.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China
8.School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
9.Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le Aldo Moro 5, 00185, Rome, Italy
10.Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131, Napoli, Italy
Recommended Citation
GB/T 7714
Arianna Di Lorenzo,Anatoly P. Sobolev,Seyed Fazel Nabavi,et al. Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression[C],2019:434-443.
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