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一类苄泽修饰壳聚糖嫁接物及其制备方法、 应用
余华; 王一涛; 熊炜
2019-03-19
Rights Holder澳门大学
Date Available2019-03-19
Country中国
Subtype发明专利
Contribution Rank1
Abstract

本发明提供苄泽修饰壳聚糖嫁接物,通过两 步反应以丁二酸将苄泽末端羟基与壳聚糖中氨 基发生化学键合,生成苄泽修饰壳聚糖嫁接物。 苄泽修饰壳聚糖嫁接物通过自聚集方法和静电 吸引与负电性多聚磷酸钠复合形成纳米递释系 统。苄泽的修饰使得此嫁接物具有P糖蛋白外排 的抑制作用,提高小肠上皮细胞的摄取,以增加 药物的吸收,从而提高药物生物利用度提高疗 效。该纳米递送系统具有显著的抑制P糖蛋白底 物外排能力,可在口服药物中应用。

Application Date2018-09-04
Patent NumberCN109485748A
Language中文Chinese
Application NumberCN201811024505.6
Open (Notice) NumberCN109485748A
Patent Agent王斌
Agency北京德崇智捷知识产权代理 有限公司
Document TypePatent
CollectionInstitute of Chinese Medical Sciences
Affiliation澳門大學中華醫藥研究院
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
余华,王一涛,熊炜. 一类苄泽修饰壳聚糖嫁接物及其制备方法、 应用. CN109485748A[P]. 2019-03-19.
APA 余华,王一涛,&熊炜.(2018-09-04).一类苄泽修饰壳聚糖嫁接物及其制备方法、 应用.
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