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Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
Gao,Cheng; Huang,Qiaoxian; Liu,Conghui; Kwong,Cheryl H.T.; Yue,Ludan; Wan,Jian Bo; Lee,Simon M.Y.; Wang,Ruibing
2020-05-26
Source PublicationNature Communications
ISSN2041-1723
Volume11Issue:1
Abstract

Vascular disease remains the leading cause of death and disability, the etiology of which often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy has limited therapeutic efficacy. Here we report a biomimetic drug delivery system derived from macrophage membrane coated ROS-responsive nanoparticles (NPs). The macrophage membrane not only avoids the clearance of NPs from the reticuloendothelial system, but also leads NPs to the inflammatory tissues, where the ROS-responsiveness of NPs enables specific payload release. Moreover, the macrophage membrane sequesters proinflammatory cytokines to suppress local inflammation. The synergistic effects of pharmacotherapy and inflammatory cytokines sequestration from such a biomimetic drug delivery system lead to improved therapeutic efficacy in atherosclerosis. Comparison to macrophage internalized with ROS-responsive NPs, as a live-cell based drug delivery system for treatment of atherosclerosis, suggests that cell membrane coated drug delivery approach is likely more suitable for dealing with an inflammatory disease than the live-cell approach.

DOI10.1038/s41467-020-16439-7
URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000538809900012
Scopus ID2-s2.0-85085284000
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Cited Times [WOS]:99   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee,Simon M.Y.; Wang,Ruibing
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gao,Cheng,Huang,Qiaoxian,Liu,Conghui,et al. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines[J]. Nature Communications,2020,11(1).
APA Gao,Cheng,Huang,Qiaoxian,Liu,Conghui,Kwong,Cheryl H.T.,Yue,Ludan,Wan,Jian Bo,Lee,Simon M.Y.,&Wang,Ruibing.(2020).Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines.Nature Communications,11(1).
MLA Gao,Cheng,et al."Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines".Nature Communications 11.1(2020).
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