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Cytotoxic triterpenoids from: Antrodia camphorata as sensitizers of paclitaxel
Li,Bin1; Kuang,Yi1; Zhang,Meng1; He,Jun Bin1; Xu,Lu Lu1; Leung,Chung Hang2; Ma,Dik Lung3; Lo,Jen Yu4; Qiao,Xue1; Ye,Min1
2020-03-07
Source PublicationOrganic Chemistry Frontiers
ISSN2052-4110
Volume7Issue:5Pages:768-779
Abstract

In an attempt to discover anticancer triterpenoids from the medicinal fungus Antrodia camphorata, a total of 60 triterpenoids (1-60) including 18 new ones (antcamphins M-X, 1-18) were isolated from its dish cultures. The structures of the new compounds were elucidated by extensive NMR and HRESIMS data analyses. The absolute configurations were established by the modified Mosher's method, chemical transformation, or X-ray crystallographic data analysis. The cytotoxic activities of 1-60, together with previously reported compounds 61-81, were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7 cells). Compound 57 exhibited potent activities against all the four cell lines with IC values of 2.6, 8.2, 2.5, and 4.6 μM, respectively. Moreover, the combination of 10 and 69 (20 μM) could remarkably enhance their cytotoxic activities against the HL60 cells of paclitaxel (10 nM), with inhibition rates increasing from 19.6% to 58.2% and 70.6%, respectively.

DOI10.1039/c9qo01516g
URLView the original
Indexed BySCIE ; IC
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000519553300006
Scopus ID2-s2.0-85081118749
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorQiao,Xue; Ye,Min
Affiliation1.State Key Laboratory of Natural and Biomimetic Drugs,Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,School of Pharmaceutical Sciences,Peking University,Beijing,38 Xueyuan Road,100191,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
3.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,Hong Kong
4.Honest and Humble Biotechnology Co.,Ltd.,New Taipei City,72 Dazhong Street,251,Taiwan
Recommended Citation
GB/T 7714
Li,Bin,Kuang,Yi,Zhang,Meng,et al. Cytotoxic triterpenoids from: Antrodia camphorata as sensitizers of paclitaxel[J]. Organic Chemistry Frontiers,2020,7(5):768-779.
APA Li,Bin,Kuang,Yi,Zhang,Meng,He,Jun Bin,Xu,Lu Lu,Leung,Chung Hang,Ma,Dik Lung,Lo,Jen Yu,Qiao,Xue,&Ye,Min.(2020).Cytotoxic triterpenoids from: Antrodia camphorata as sensitizers of paclitaxel.Organic Chemistry Frontiers,7(5),768-779.
MLA Li,Bin,et al."Cytotoxic triterpenoids from: Antrodia camphorata as sensitizers of paclitaxel".Organic Chemistry Frontiers 7.5(2020):768-779.
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