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Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata
Li,Bin1; Kuang,Yi1; He,Jun Bin1; Tang,Rui1; Xu,Lu Lu1; Leung,Chung Hang2; Ma,Dik Lung3; Qiao,Xue1; Ye,Min1
Source PublicationJournal of Natural Products

Antrodia camphorata is a rare and valuable medicinal mushroom. In this work, 11 new triterpenoids, namely, antcamphorols A-K (1-11), together with 10 known triterpenoids, 12-21, were isolated from dish-cultured A. camphorata. Compound 1 is an unprecedented C lanostane-type triterpenoid featuring a methyl group at C-15 and a C-21-O-C-24 tetrahydropyran ring at C-17. Compounds 2-11 are ergostane-type triterpenoids, and they include two pairs of norergostanes 2-5. The structures of the new compounds were identified by NMR, 2D NMR, and HRESIMS data analyses. The absolute configurations of 1 and 6 were defined by X-ray diffraction data, and the absolute configuration at C-25 of 4 was determined by the modified Mosher's method. Compounds 7, 9, 10, 16, and 19 showed significant ROS scavenging activities (63.9-70.5% at 20 μM) in high-glucose-induced HUVECs. Compounds 3 and 8 exhibited moderate cytotoxic activities against U251 (IC, 9.2 μM) and MCF-7 (IC, 8.1 μM) human cancer cell lines, respectively.

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Indexed BySCIE ; IC
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000510076700008
Scopus ID2-s2.0-85078384749
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorQiao,Xue; Ye,Min
Affiliation1.State Key Laboratory of Natural and Biomimetic Drugs,Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,School of Pharmaceutical Sciences,Peking University,Beijing,38 Xueyuan Road,100191,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
3.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,SWT 802,Hong Kong
Recommended Citation
GB/T 7714
Li,Bin,Kuang,Yi,He,Jun Bin,et al. Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata[J]. Journal of Natural Products,2020,83(1):45-54.
APA Li,Bin,Kuang,Yi,He,Jun Bin,Tang,Rui,Xu,Lu Lu,Leung,Chung Hang,Ma,Dik Lung,Qiao,Xue,&Ye,Min.(2020).Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata.Journal of Natural Products,83(1),45-54.
MLA Li,Bin,et al."Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata".Journal of Natural Products 83.1(2020):45-54.
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