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Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening
Wu,Ke Jia1; Lei,Pui Man1; Liu,Hao2; Wu,Chun2; Leung,Chung Hang1; Ma,Dik Lung2
2019-12-04
Source PublicationMolecules
ISSN1420-3049
Volume24Issue:24
Abstract

As protein-protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors. In this review, we discuss recent advances in the application of virtual screening for identifying mimics of protein partners. The classification and function of the mimicking protein partner inhibitor discovery by virtual screening are described. We anticipate that this review would be of interest to medicinal chemists and chemical biologists working in the field of protein-protein interaction inhibitors or probes.

KeywordDrug Discovery Mimetics Protein-protein Interactions Virtual Screening
DOI10.3390/molecules24244428
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Biochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000507299600006
Scopus ID2-s2.0-85076294555
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung,Chung Hang; Ma,Dik Lung
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,999078,Macao
2.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,999077,Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu,Ke Jia,Lei,Pui Man,Liu,Hao,et al. Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening[J]. Molecules,2019,24(24).
APA Wu,Ke Jia,Lei,Pui Man,Liu,Hao,Wu,Chun,Leung,Chung Hang,&Ma,Dik Lung.(2019).Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening.Molecules,24(24).
MLA Wu,Ke Jia,et al."Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening".Molecules 24.24(2019).
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