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Experimental alcoholism primes structural and functional impairment of the glymphatic pathway
Liu,Qiang1; Yan,Lingli1; Huang,Miaodan1; Zeng,Haitao2; Satyanarayanan,Senthil Kumaran1; Shi,Zhe1; Chen,Dingbang3; Lu,Jia Hong1; Pei,Zhong3; Yao,Xiaoli3; Su,Huanxing1
2020-03-01
Source PublicationBrain, Behavior, and Immunity
ISSN0889-1591
Volume85Pages:106-119
Abstract

Alcoholism is a risk factor for the development of cognitive decline and dementia. Here we demonstrated that the glymphatic function in the brain was impaired by alcohol administration. Acute moderate alcohol administration substantially retarded and reduced the entry of subarachnoid cerebrospinal fluid (CSF) via the paravascular space into the cerebral parenchyma, thus impaired CSF-interstitial fluid (ISF) exchange and parenchymal amyloid β (Aβ) peptide clearance. The elevated release of β-endorphin and reduced cerebrovascular pulsatility after acute alcohol administration may account for the impairment of the glymphatic function. Chronic moderate alcohol consumption led to pronounced activation of astrocytes and a widespread loss of perivascular AQP4 polarization in the brain, which results in an irreversible impairment of the glymphatic function. The results of the study suggest that impaired glymphatic functions and reduced parenchymal Aβ clearance found in both acute and chronic alcohol treatment may contribute to the development of cognitive decline and dementia in alcoholism.

KeywordAlcoholism Aqp4 Polarization Aβ Clearance Csf-isf Exchange
DOI10.1016/j.bbi.2019.06.029
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaImmunology ; Psychiatry ; Neurosciences & Neurology
WOS SubjectImmunology ; Neurosciences ; Psychiatry
WOS IDWOS:000527886000012
Scopus ID2-s2.0-85067898640
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu,Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.Center for Reproductive Medicine,The Sixth Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510080,China
3.Department of Neurology,National Key Clinical Department and Key Discipline of Neurology,The First Affiliated Hospital Sun Yat-Sen University,Guangzhou,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu,Qiang,Yan,Lingli,Huang,Miaodan,et al. Experimental alcoholism primes structural and functional impairment of the glymphatic pathway[J]. Brain, Behavior, and Immunity,2020,85:106-119.
APA Liu,Qiang,Yan,Lingli,Huang,Miaodan,Zeng,Haitao,Satyanarayanan,Senthil Kumaran,Shi,Zhe,Chen,Dingbang,Lu,Jia Hong,Pei,Zhong,Yao,Xiaoli,&Su,Huanxing.(2020).Experimental alcoholism primes structural and functional impairment of the glymphatic pathway.Brain, Behavior, and Immunity,85,106-119.
MLA Liu,Qiang,et al."Experimental alcoholism primes structural and functional impairment of the glymphatic pathway".Brain, Behavior, and Immunity 85(2020):106-119.
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