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Transplantation of ACE2- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia
Leng,Zikuan1,5; Zhu,Rongjia2; Hou,Wei3; Feng,Yingmei3; Yang,Yanlei4; Han,Qin2; Shan,Guangliang2; Meng,Fanyan1; Du,Dongshu1; Wang,Shihua2; Fan,Junfen2; Wang,Wenjing3; Deng,Luchan2; Shi,Hongbo3; Li,Hongjun3; Hu,Zhongjie3; Zhang,Fengchun4; Gao,Jinming4; Liu,Hongjian5; Li,Xiaoxia6; Zhao,Yangyang2; Yin,Kan6; He,Xijing7; Gao,Zhengchao7; Wang,Yibin7; Yang,Bo8; Jin,Ronghua3; Stambler,Ilia9,10,11; Lim,Lee Wei9,10,12; Su,Huanxing9,10,13; Moskalev,Alexey9,10,14; Cano,Antonio9,10,15; Chakrabarti,Sasanka16; Min,Kyung Jin9,10,17; Ellison-Hughes,Georgina9,10,18; Caruso,Calogero9,10,19; Jin,Kunlin9,10,20; Zhao,Robert Chunhua1,2,9,10
Source PublicationAging and Disease

A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improves the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China, from Jan 23, 2020 to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients without observed adverse effects. The pulmonary function and symptoms of these seven patients were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. In addition, a group of CD14+CD11c+CD11b regulatory DC cell population dramatically increased. Meanwhile, the level of TNF-α was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2- and TMPRSS2- which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.

KeywordAce2 Negative Cell Transplantation Covid-19 Function Recovery Immunomodulation Mesenchymal Stem Cells
URLView the original
Indexed BySCIE
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:000520029200001
Scopus ID2-s2.0-85082424283
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Cited Times [WOS]:651   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLiu,Hongjian; Jin,Ronghua; Jin,Kunlin; Zhao,Robert Chunhua
Affiliation1.School of Life Sciences,Shanghai University,Shanghai,China
2.Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing,China
3.Beijing YouAn Hospital,Capital Medical University,Beijing,China
4.Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,China
5.Department of Orthopaedics,First Affiliated Hospital of Zhengzhou University,Zhengzhou,China
6.Institute of Stem Cell and Regeneration Medicine,School of Basic Medicine,Qingdao University,Shandong,China
7.Department of Orthopaedics,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China
8.Department of Neurosurgery,First Affiliated Hospital of Zhengzhou University,Zhengzhou,China
9.Executive Committee on Anti-aging and Disease Prevention in the Framework of Science and Technology,Pharmacology and Medicine Themes Under an Interactive,UNESCO,Paris,Atlas along the Silk Roads,France
10.International Society on Aging and Disease,Fort Worth,United States
11.Geriatric Medical Center
12.School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,University of Hong Kong,Hong Kong
13.Institute of Chinese Medical Science,University of Macau,Taipa,Macao
14.Institute of Biology,Komi Science Center,Russian Academy of Sciences,Syktyvkar,Russian Federation
15.Department of Pediatrics,Obstetrics and Gynecology,University of Valencia,Valencia,Spain
16.Maharishi Markandeshwar Deemed University,Mullana-Ambala,India
17.Department of Biological Sciences,Inha University,Incheon,South Korea
18.Faculty of Life Sciences and Medicine,King's College London,London,United Kingdom
19.Department of Biomedicine,Neuroscience and Advanced Diagnostics,University of Palermo,Palermo,Italy
20.University of North Texas,Health Science Center,Fort Worth,TX76107,United States
Recommended Citation
GB/T 7714
Leng,Zikuan,Zhu,Rongjia,Hou,Wei,et al. Transplantation of ACE2- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia[J]. Aging and Disease,2020,11(2):216-228.
APA Leng,Zikuan.,Zhu,Rongjia.,Hou,Wei.,Feng,Yingmei.,Yang,Yanlei.,Han,Qin.,Shan,Guangliang.,Meng,Fanyan.,Du,Dongshu.,Wang,Shihua.,Fan,Junfen.,Wang,Wenjing.,Deng,Luchan.,Shi,Hongbo.,Li,Hongjun.,Hu,Zhongjie.,Zhang,Fengchun.,Gao,Jinming.,Liu,Hongjian.,...&Zhao,Robert Chunhua.(2020).Transplantation of ACE2- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia.Aging and Disease,11(2),216-228.
MLA Leng,Zikuan,et al."Transplantation of ACE2- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia".Aging and Disease 11.2(2020):216-228.
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