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Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: A meta-analysis
Xiong,Jianping1; Zhang,Haoaohai1; Wang,Yaqin2; Wang,Anqiang1; Bian,Jin1; Huang,Hanchun1; Zheng,Ying3; Sang,Xinting1; Xu,Yiyao1; Lu,Xin1; Zhao,Haitao1
Source PublicationOncotarget

Some studies have reported that hepatitis B virus (HBV) infection affects the risk of nonalcoholic fatty liver disease (NAFLD). However, this association is controversial. We conducted a systematic review and meta-analysis to investigate the relationship between HBV infection and NAFLD. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. We used the random-effects model proposed by DerSimonian and Laird to quantify the relationship between HBV infection and risk of NAFLD. We also conducted subgroup and sensitivity analyses to validate the stability of the results. Five articles, comprising 8,272 HBVinfected patients and 111,631 uninfected controls, were included in our research. Our meta-analysis suggested that the risk of NAFLD was significantly lower in HBVinfected patients than in uninfected controls, with heterogeneity between studies (summary odds ratio [OR] = 0.71; confidence interval [CI] = 0.53-0.90; I2 = 75.2%). However, the inverse relationship was observed in only cohort (OR = 0.83; 95% CI = 0.73-0.94) and cross-sectional studies (OR = 0.63; 95% CI = 0.47-0.79), not case-control studies (OR = 3.96; 95% CI = 2.10-7.48). In conclusion, HBV infection was inversely associated with the risk of NAFLD.

KeywordHepatitis b Virus Meta-analysis Nonalcoholic Fatty Liver Disease
URLView the original
WOS IDWOS:000419534900107
Scopus ID2-s2.0-85036664026
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorXu,Yiyao
Affiliation1.Department of Liver Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
2.Department of Interventional Radiology,The First Affiliated Hospital of China Medical University,Shenyang,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Science,University of Macau,Macau,Macao
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GB/T 7714
Xiong,Jianping,Zhang,Haoaohai,Wang,Yaqin,et al. Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: A meta-analysis[J]. Oncotarget,2017,8(63):107295-107302.
APA Xiong,Jianping,Zhang,Haoaohai,Wang,Yaqin,Wang,Anqiang,Bian,Jin,Huang,Hanchun,Zheng,Ying,Sang,Xinting,Xu,Yiyao,Lu,Xin,&Zhao,Haitao.(2017).Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: A meta-analysis.Oncotarget,8(63),107295-107302.
MLA Xiong,Jianping,et al."Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: A meta-analysis".Oncotarget 8.63(2017):107295-107302.
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