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Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway
Jia,Xuejing1,2; Zhang,Chao2,3; Bao,Jiaolin2; Wang,Kai2; Tu,Yanbei2; Wan,Jian Bo2; He,Chengwei2
2020-02-01
Source PublicationInflammopharmacology
ISSN0925-4692
Volume28Issue:1Pages:289-297
Abstract

Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound composition of EEF6 was determined by high-performance liquid chromatography-mass spectrometry. The result showed that five flavonoids compounds, 2′,4′,5,7-tetrahydroxyisoflavone, genistein-8-C-glucopyranoside, tricin, genistein, and daidzein, were identified in EEF6. In addition, EEF6 exhibited potent anti-inflammatory ability against LPS-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathways by decreasing the secretion of nitric oxide (NO), interleukin (IL)-6, TNF-α, and monocyte chemotactic protein (MCP)-1, inhibiting the translocation of p65 from cytoplasm to nucleus, and suppressing the phosphorylation of ERK, JNK, and p38. These results indicated that EEF6 could be a promising ingredient for inflammation management.

KeywordAnti-inflammation Flavonoids Mapk Nf-κb Rhynchosia Minima Root
DOI10.1007/s10787-019-00632-2
URLView the original
Indexed BySCIE
WOS Research AreaImmunology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectImmunology ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000511960600020
Scopus ID2-s2.0-85070943208
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHe,Chengwei
Affiliation1.College of Food Science and Technology,Guangdong Ocean University,Zhanjiang,524088,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,999078,China
3.School of Life Sciences,Beijing University of Chinese Medicine,Beijing,100029,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Jia,Xuejing,Zhang,Chao,Bao,Jiaolin,et al. Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway[J]. Inflammopharmacology,2020,28(1):289-297.
APA Jia,Xuejing,Zhang,Chao,Bao,Jiaolin,Wang,Kai,Tu,Yanbei,Wan,Jian Bo,&He,Chengwei.(2020).Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway.Inflammopharmacology,28(1),289-297.
MLA Jia,Xuejing,et al."Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway".Inflammopharmacology 28.1(2020):289-297.
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