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A pharmacological review of dicoumarol: An old natural anticoagulant agent
Sun,Chong2; Zhao,Wenwen1; Wang,Xumei2; Sun,Yinxiang3; Chen,Xiuping1,2
Source PublicationPharmacological Research

Dicoumarol is an oral anticoagulant agent prescribed in clinical for decades. It is a natural hydroxycoumarin discovered from the spoilage of Melilotus officinalis (L.) Pall and is originally discovered as a rodenticide. Due to its structural similarity to that of vitamin K, it significantly inhibits vitamin K epoxide reductase and acts as a vitamin K antagonist. Dicoumarol is mainly used as an anticoagulant to prevent thrombogenesis and to cure vascular thrombosis. Other biological activities besides anticoagulants such as anticancer, antimicrobial, antiviral, etc., have also been documented. The side effects of dicoumarol raise safety concerns for clinical application. In this review, the physicochemical property, the pharmacological activities, the side effects, and the pharmacokinetics of dicoumarol were summarized, aiming to provide a whole picture of the “old” anticoagulant.

KeywordBioactivity Dicoumarol Pharmacokinetic Side Effects
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000598124500011
Scopus ID2-s2.0-85091769774
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSun,Yinxiang; Chen,Xiuping
Affiliation1.School of Basic Medicine,Qingdao University,Qingdao,266071,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
3.Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University),Zhuhai,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Sun,Chong,Zhao,Wenwen,Wang,Xumei,et al. A pharmacological review of dicoumarol: An old natural anticoagulant agent[J]. Pharmacological Research,2020,160.
APA Sun,Chong,Zhao,Wenwen,Wang,Xumei,Sun,Yinxiang,&Chen,Xiuping.(2020).A pharmacological review of dicoumarol: An old natural anticoagulant agent.Pharmacological Research,160.
MLA Sun,Chong,et al."A pharmacological review of dicoumarol: An old natural anticoagulant agent".Pharmacological Research 160(2020).
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