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Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds
Yu,Jie1; Zhong,Bingling1; Xiao,Qingwen1; Du,Lida2; Hou,Ying1; Sun,Hong Shuo2; Lu,Jin Jian1; Chen,Xiuping1
Source PublicationPharmacology and Therapeutics

Cell death plays a critical role in organism development and the pathogenesis of diseases. Necrosis is considered a non-programmed cell death in an extreme environment. Recent advances have provided solid evidence that necrosis could be programmed and quite a few types of programmed necrosis, such as necroptosis, ferroptosis, pyroptosis, paraptosis, mitochondrial permeability transition-driven necrosis, and oncosis, have been identified. The specific biomarkers, detailed signaling, and precise pathophysiological importance of programmed necrosis are yet to be clarified, but these forms of necrosis provide novel strategies for the treatment of various diseases, including cancer. Natural compounds are a unique source of lead compounds for the discovery of anti-cancer drugs. Natural compounds can induce both apoptosis and programmed necrosis. In this review, we summarized the recent progress of programmed necrosis and introduced their natural inducers. Noptosis, which is a novel type of programmed necrosis that is strictly dependent on NAD(P)H: quinone oxidoreductase 1-derived oxidative stress was proposed. Furthermore, the anti-cancer strategies that take advantage of programmed necrosis and the main concerns from the scientific community in this regard were discussed.

KeywordCancer Natural Compounds Programmed Necrosis
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000570067100008
Scopus ID2-s2.0-85086319743
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Xiuping
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,China
2.Department of Surgery,University of Toronto,Canada
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yu,Jie,Zhong,Bingling,Xiao,Qingwen,et al. Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds[J]. Pharmacology and Therapeutics,2020,214.
APA Yu,Jie,Zhong,Bingling,Xiao,Qingwen,Du,Lida,Hou,Ying,Sun,Hong Shuo,Lu,Jin Jian,&Chen,Xiuping.(2020).Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds.Pharmacology and Therapeutics,214.
MLA Yu,Jie,et al."Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds".Pharmacology and Therapeutics 214(2020).
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