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Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells
CHEN,Yu Chi1; HUANG,Mu Yang1; ZHANG,Le Le1,2; FENG,Zhe Ling1; JIANG,Xiao Ming1; YUAN,Luo Wei1; HUANG,Run Yue3; LIU,Bo3; YU,Hua1; WANG,Yi Tao1; CHEN,Xiu Ping1; LIN,Li Gen1; LU,Jin Jian1
2020-07
Source PublicationChinese Journal of Natural Medicines
ISSN2095-6975
Volume18Issue:7Pages:517-525
Abstract

Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell membrane. Mechanistically, NLE increased the phosphorylation and expression of c-Jun, and promoted the localization of c-Jun in the nucleus, while silencing of c-Jun by small interfering RNA (siRNA) reduced NLE-induced PD-L1. Further study showed that NLE activated the c-Jun N-terminal kinases (JNK), the upstream of c-Jun, and its inhibitor SP600125 reversed the NLE-increased PD-L1. Moreover, NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell surface. In summary, NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-Jun axis, which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer.

KeywordC-jun Jnk Lung Cancer Nagilactone e Programmed Death Ligand 1
DOI10.1016/S1875-5364(20)30062-5
URLView the original
Indexed BySCIE
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000568954000006
Scopus ID2-s2.0-85086938397
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLU,Jin Jian
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,999078,China
2.School of Medicine,Chengdu University,Chengdu,610106,China
3.The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine),Guangzhou,510120,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
CHEN,Yu Chi,HUANG,Mu Yang,ZHANG,Le Le,et al. Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells[J]. Chinese Journal of Natural Medicines,2020,18(7):517-525.
APA CHEN,Yu Chi,HUANG,Mu Yang,ZHANG,Le Le,FENG,Zhe Ling,JIANG,Xiao Ming,YUAN,Luo Wei,HUANG,Run Yue,LIU,Bo,YU,Hua,WANG,Yi Tao,CHEN,Xiu Ping,LIN,Li Gen,&LU,Jin Jian.(2020).Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells.Chinese Journal of Natural Medicines,18(7),517-525.
MLA CHEN,Yu Chi,et al."Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells".Chinese Journal of Natural Medicines 18.7(2020):517-525.
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