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The development of small-molecule inhibitors targeting CD47
Yu,Wei Bang; Ye,Zi Han; Chen,Xiuping; Shi,Jia Jie; Lu,Jin Jian
2021-02
Source PublicationDrug Discovery Today
ISSN1359-6446
Volume26Issue:2Pages:561-568
Abstract

Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as ‘don't eat me’ signal to protect cells from phagocytosis upon interaction with signal regulatory protein alpha (SIRPα) on macrophages, has recently attracted much attention. Numerous antibodies targeting the CD47/SIRPα axis have shown encouraging efficacy in clinical trials. Meanwhile, studies on small-molecule inhibitors that interfere with CD47/SIRPα interaction or regulate CD47 expression are also in full swing. In this review, we summarize the small-molecule inhibitors interrupting the binding of CD47/SIRPα and regulating CD47 at the transcriptional, translational, and post-translational modification (PTM) levels. We provide perspectives and strategies for targeting the CD47/SIRPα phagocytosis checkpoint.

DOI10.1016/j.drudis.2020.11.003
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000632648800003
Scopus ID2-s2.0-85096866036
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Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorShi,Jia Jie; Lu,Jin Jian
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yu,Wei Bang,Ye,Zi Han,Chen,Xiuping,et al. The development of small-molecule inhibitors targeting CD47[J]. Drug Discovery Today,2021,26(2):561-568.
APA Yu,Wei Bang,Ye,Zi Han,Chen,Xiuping,Shi,Jia Jie,&Lu,Jin Jian.(2021).The development of small-molecule inhibitors targeting CD47.Drug Discovery Today,26(2),561-568.
MLA Yu,Wei Bang,et al."The development of small-molecule inhibitors targeting CD47".Drug Discovery Today 26.2(2021):561-568.
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