Research and development of antibiotics: Insights from patents and citation network
Zhang,Meng1; Kong,Xiangjun2; Zheng,Jun3; Wan,Jian Bo2; Wang,Yitao2; Hu,Yuanjia2; Shao,Rong1
Source PublicationExpert Opinion on Therapeutic Patents
AbstractBacterial resistance to antibiotics develops at an alarming rate and leads to the increasing morbidity and health-care costs in recent years. However, the global research and development (RandD) of antibiotics has fallen behind the emergence and spread of bacterial resistance and the world is heading towards a 'post-antibiotic era'. In this context, systematic understanding of the technology landscape and evolving process of antibiotic RandD may help to provide insights for discovering future antibiotics more rationally.Areas covered: Patents and patent citations are broadly believed to be powerful tools in representing the technology advances and capturing technology flows. In all, 707 U.S. patents related to antibiotic RandD are collected and analyzed. Furthermore, patent citations are visualized by a network-based approach, while the inter-relationship between patented technologies on antibiotics is further revealed.Expert opinion: The current dry pipeline of antibiotic development requires substantial awareness and political support. It is essential to build an attractive and supportive environment for investment. Thus, a new antibiotic business model is needed to chase the balance between the market-oriented investment and public health goals. Additionally, drug development targeting Gram-negative bacteria, especially resistant Gram-negative bacteria, demands attentions from stakeholders because of their unmet medical needs.
KeywordAntibiotics patent patent citation network technology flows technology landscape
URLView the original
Scopus ID2-s2.0-84963997585
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorShao,Rong
Affiliation1.School of International Pharmaceutical Business,China Pharmaceutical University,Research Center of National Drug Policy and Ecosystem,Nanjing, Jiangsu,211198,China
2.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,999078,Macao
3.Faculty of Health Sciences,University of Macau,Macao
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GB/T 7714
Zhang,Meng,Kong,Xiangjun,Zheng,Jun,et al. Research and development of antibiotics: Insights from patents and citation network[J]. Expert Opinion on Therapeutic Patents,2016,26(5):617-627.
APA Zhang,Meng,Kong,Xiangjun,Zheng,Jun,Wan,Jian Bo,Wang,Yitao,Hu,Yuanjia,&Shao,Rong.(2016).Research and development of antibiotics: Insights from patents and citation network.Expert Opinion on Therapeutic Patents,26(5),617-627.
MLA Zhang,Meng,et al."Research and development of antibiotics: Insights from patents and citation network".Expert Opinion on Therapeutic Patents 26.5(2016):617-627.
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