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The drug likeness analysis of anti-inflammatory clerodane diterpenoids
Feng,Zheling; Cao,Jun; Zhang,Qingwen; Lin,Ligen
2020-12-09
Source PublicationChinese Medicine (United Kingdom)
ISSN1749-8546
Volume15Issue:1
Abstract

Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it’s urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.

KeywordAnti-inflammation Clerodane Diterpenoids Drug-likeness Swissadme
DOI10.1186/s13020-020-00407-w
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000597828300001
Scopus ID2-s2.0-85097409842
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin,Ligen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Avenida da Universidade,Taipa,999078,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Feng,Zheling,Cao,Jun,Zhang,Qingwen,et al. The drug likeness analysis of anti-inflammatory clerodane diterpenoids[J]. Chinese Medicine (United Kingdom),2020,15(1).
APA Feng,Zheling,Cao,Jun,Zhang,Qingwen,&Lin,Ligen.(2020).The drug likeness analysis of anti-inflammatory clerodane diterpenoids.Chinese Medicine (United Kingdom),15(1).
MLA Feng,Zheling,et al."The drug likeness analysis of anti-inflammatory clerodane diterpenoids".Chinese Medicine (United Kingdom) 15.1(2020).
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