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Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax
Xu,Yunshao1; Shi,Wei1; Feng,Lu2; Cao,Jun1; Feng,Zheling1; Zhang,Qingwen1; Lu,Jinjian1; Ye,Yang2,3; Lin,Ligen1
2022-02-16
Source PublicationNatural Product Research
ISSN1478-6419
Volume36Issue:4Pages:932-941
Abstract

The seeds of Caesalpinia minax Hance have shown anti-tumor potential, while the chemical principle is still unknown. In a search for anti-tumor compounds, six new cassane-type diterpenoids, 12-demethylcaesalpin G (1), caesalpinolide H (2), 12-demethylcaesalpin H (3), caesalpinolide J (4), 12-O-ethyl neocaesalpin B (5), and 3-deacetyldecapetpene B (6), were isolated from the seeds of C. minax Hance, along with fifteen known analogues. The structures of the new compounds were established by means of spectroscopic techniques (NMR, HRESIMS and IR). The absolute configurations of the new compounds were determined by their ECD spectra. All of the new compounds were tested for their anti-proliferative activity against human lung cancer A549 cells, breast cancer MCF-7 cells, and ovarian cancer HEY cells. The results indicated that only compound 6 displayed moderate cytotoxicity against three cancer cell lines. Thus, the opening of furan ring in cassane-type diterpenoids might enhance the cytotoxic activity.

KeywordCaesalpinia Minax Cassane Diterpenoids Cytotoxic Activity Fabaceae
DOI10.1080/14786419.2020.1853729
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000596647100001
Scopus ID2-s2.0-85096963555
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin,Ligen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.State Key Laboratory of Drug Research,& Natural Products Chemistry Department,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China
3.School of Life Science and Technology,Shanghai Tech University,Shanghai,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu,Yunshao,Shi,Wei,Feng,Lu,et al. Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax[J]. Natural Product Research,2022,36(4):932-941.
APA Xu,Yunshao,Shi,Wei,Feng,Lu,Cao,Jun,Feng,Zheling,Zhang,Qingwen,Lu,Jinjian,Ye,Yang,&Lin,Ligen.(2022).Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax.Natural Product Research,36(4),932-941.
MLA Xu,Yunshao,et al."Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax".Natural Product Research 36.4(2022):932-941.
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