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Targeting ATG4 in cancer therapy
Fu,Yuanyuan1; Huang,Zhiying1; Hong,Liang1; Lu,Jia Hong2; Feng,Du3; Yin,Xiao Ming4; Li,Min1
Source PublicationCancers

Autophagy is a lysosome-mediated degradation pathway that enables the degradation and recycling of cytoplasmic components to sustain metabolic homoeostasis. Recently, autophagy has been reported to have an astonishing number of connections to cancer, as tumor cells require proficient autophagy in response to metabolic and therapeutic stresses to sustain cell proliferation. Autophagy-related gene 4 (ATG4) is essential for autophagy by affecting autophagosome formation through processing full-length microtubule-associated protein 1A/1B-light chain 3 (pro-LC3) and lipidated LC3. An increasing amount of evidence suggests that ATG4B expression is elevated in certain types of cancer, implying that ATG4B is a potential anticancer target. In this review, we address the central roles of ATG4B in the autophagy machinery and in targeted cancer therapy. Specifically, we discuss how pharmacologically inhibiting ATG4B can benefit cancer therapies.

KeywordAtg4 Atg4b Autophagy Cancer Therapy
URLView the original
Indexed BySCIE
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000472738300062
Scopus ID2-s2.0-85066999604
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYin,Xiao Ming; Li,Min
Affiliation1.School of Pharmaceutical Sciences,Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,Sun Yat-Sen University,Guangzhou,510006,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,China
3.State Key Laboratory of Respiratory Disease,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou,511436,China
4.Department of Pathology,Laboratory Medicine,Indiana University,School of Medicine,Indianapolis,46202,United States
Recommended Citation
GB/T 7714
Fu,Yuanyuan,Huang,Zhiying,Hong,Liang,et al. Targeting ATG4 in cancer therapy[J]. Cancers,2019,11(5).
APA Fu,Yuanyuan,Huang,Zhiying,Hong,Liang,Lu,Jia Hong,Feng,Du,Yin,Xiao Ming,&Li,Min.(2019).Targeting ATG4 in cancer therapy.Cancers,11(5).
MLA Fu,Yuanyuan,et al."Targeting ATG4 in cancer therapy".Cancers 11.5(2019).
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