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Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms
Huang,Mu Yang1; Jiang,Xiao Ming1; Wang,Bing Lin2; Sun,Yang2; Lu,Jin Jian1
2021-03-01
Source PublicationPharmacology and Therapeutics
ISSN0163-7258
Volume219
Abstract

Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade has been approved as the standard-of-care for the treatment of non-small cell lung cancer (NSCLC). Yet, the population of patients who benefit from the treatment remains modest, some of whom would get relapsed and progressed eventually. Combination therapy has emerged as an effective way to broaden beneficiaries from PD-1/PD-L1 immunotherapy and overcome or delay the resistance. In this review, we discuss the PD-1/PD-L1 blockade in combination with conventional chemotherapy, targeted therapy or immunotherapy. Meanwhile, we illustrate their underlying mechanisms in regulating the process of the cancer-immunity cycle, providing the rationale for the PD-1/PD-L1 blockade-based combination therapy. The challenges of combination regimens are also addressed.

KeywordChallenge Combination Therapy Immunotherapy Mechanism Nsclc Pd-1/pd-l1
DOI10.1016/j.pharmthera.2020.107694
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000619674700005
Scopus ID2-s2.0-85091875436
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,China
2.State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Science,Nanjing University,Nanjing,163 Xianlin Avenue,210023,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang,Mu Yang,Jiang,Xiao Ming,Wang,Bing Lin,et al. Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms[J]. Pharmacology and Therapeutics,2021,219.
APA Huang,Mu Yang,Jiang,Xiao Ming,Wang,Bing Lin,Sun,Yang,&Lu,Jin Jian.(2021).Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms.Pharmacology and Therapeutics,219.
MLA Huang,Mu Yang,et al."Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms".Pharmacology and Therapeutics 219(2021).
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