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Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets
Zeng,Chenming1; Zhao,Chenxi1; Ge,Fujing1; Li,Yuekang1; Cao,Ji1; Ying,Meidan1; Lu,Jinjian2; He,Qiaojun1; Yang,Bo1; Dai,Xiaoyang3; Zhu,Hong1
Source PublicationFrontiers in Pharmacology

Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly function by cutting ubiquitin chains of the substrates. The Machado-Joseph domain-containing proteases (MJDs) is one of the sub-families of DUBs, consisting of four members, namely, Ataxin-3, Ataxin-3L, JOSD1, and JOSD2. Recent studies have provided new insights into biological functions of MJDs in the progression of Machado-Joseph disease or cancer diseases. In this review, we summarized the cellular functions and regulatory mechanisms of MJDs in Machado-Joseph disease and cancer pathways. Furthermore, we summarized MJDs genetic alterations in different human cancers by exploring the public databases (cBioportal). The aim of this review is to provide a comprehensive account based on our current knowledge about emerging insights into MJDs in physiology and disease, which might shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention.

KeywordCancer Therapy Cellular Functions Deubiquitinase Machado-joseph Domain-containing Proteases Mjd Disease
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000570525300001
Scopus ID2-s2.0-85090838135
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDai,Xiaoyang; Zhu,Hong
Affiliation1.Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,Macao
3.Center for Drug Safety Evaluation and Research,Zhejiang University,Hangzhou,China
Recommended Citation
GB/T 7714
Zeng,Chenming,Zhao,Chenxi,Ge,Fujing,et al. Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets[J]. Frontiers in Pharmacology,2020,11.
APA Zeng,Chenming,Zhao,Chenxi,Ge,Fujing,Li,Yuekang,Cao,Ji,Ying,Meidan,Lu,Jinjian,He,Qiaojun,Yang,Bo,Dai,Xiaoyang,&Zhu,Hong.(2020).Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets.Frontiers in Pharmacology,11.
MLA Zeng,Chenming,et al."Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets".Frontiers in Pharmacology 11(2020).
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