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Regulation of CD47 expression in cancer cells
Huang,Can Yu; Ye,Zi Han; Huang,Mu Yang; Lu,Jin Jian
Source PublicationTranslational Oncology

CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance. Targeting the phagocytosis checkpoint of CD47-SIRPα axis has shown remarkable anticancer effect in preclinical and clinical research, which indicates the potential application of CD47-SIRPα blockade for cancer treatment. In this case, the comprehensive description of the regulation of CD47 in different types of cancer cells has significant implications for furthering our understanding of the role of CD47 in cancer. Based on the current reports, we summarized the regulatory factors, i.e., cytokines, oncogenes, microRNAs as well as enzymes, of CD47 expression in cancer cells. Accordingly, we also proposed several points needing further research, hoping to provide useful insights for the future investigation on the regulation of CD47 in cancers.

KeywordCd47 Cytokine Microrna Oncogene Qpctl
URLView the original
Indexed BySCIE
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000577515200012
Scopus ID2-s2.0-85090783168
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang,Can Yu,Ye,Zi Han,Huang,Mu Yang,et al. Regulation of CD47 expression in cancer cells[J]. Translational Oncology,2020,13(12).
APA Huang,Can Yu,Ye,Zi Han,Huang,Mu Yang,&Lu,Jin Jian.(2020).Regulation of CD47 expression in cancer cells.Translational Oncology,13(12).
MLA Huang,Can Yu,et al."Regulation of CD47 expression in cancer cells".Translational Oncology 13.12(2020).
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