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Post-translational modification of KRAS: potential targets for cancer therapy
Wang,Wei hua1; Yuan,Tao1; Qian,Mei jia1; Yan,Fang jie1; Yang,Liu2; He,Qiao jun1; Yang,Bo1; Lu,Jin jian3; Zhu,Hong1
Source PublicationActa Pharmacologica Sinica

Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis. Among them, KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to intervention. Although the cognition toward KRAS remains far from complete, mounting evidence suggests that a variety of post-translational modifications regulate its activation and localization. In this review, we summarize the regulatory mode of post-translational modifications on KRAS including prenylation, post-prenylation, palmitoylation, ubiquitination, phosphorylation, SUMOylation, acetylation, nitrosylation, etc. We also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities.

KeywordAcetylation Cancer Therapy Kras Nitrosylation Oncogene Palmitoylation Phosphorylation Post-translational Modification Postprenylation Prenylation Sumoylation Ubiquitination
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Indexed BySCIE
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000580920400002
Scopus ID2-s2.0-85093112245
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhu,Hong
Affiliation1.Zhejiang Province Key Laboratory of Anti-cancer Drug Research,Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China
2.Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province,Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College,Hangzhou,310014,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
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GB/T 7714
Wang,Wei hua,Yuan,Tao,Qian,Mei jia,et al. Post-translational modification of KRAS: potential targets for cancer therapy[J]. Acta Pharmacologica Sinica,2020.
APA Wang,Wei hua,Yuan,Tao,Qian,Mei jia,Yan,Fang jie,Yang,Liu,He,Qiao jun,Yang,Bo,Lu,Jin jian,&Zhu,Hong.(2020).Post-translational modification of KRAS: potential targets for cancer therapy.Acta Pharmacologica Sinica.
MLA Wang,Wei hua,et al."Post-translational modification of KRAS: potential targets for cancer therapy".Acta Pharmacologica Sinica (2020).
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