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Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury
Zou,Jian; Wang,Sheng Peng; Wang,Yi Tao; Wan,Jian Bo
2021-02-01
Source PublicationPharmacological Research
ISSN1043-6618
Volume164
Abstract

The past decades have witnessed significant progress in understanding the process of sterile inflammation, which is dependent on a cytosolic complex termed the nucleotide-binding oligomerization domain (NOD)-like receptor containing pyrin domain 3 (NLRP3) inflammasome. Activation of NLRP3 inflammasome requires two steps, including the activation of Toll-like receptor (TLR) by its ligands, resulting in transcriptional procytokine and inflammasome component activation, and the assembly and activation of NLRP3 inflammasome triggered by various danger signals, leading to caspase-1 activation, which could subsequently cleave procytokines into their active forms. Metabolic disorders, ischemia and reperfusion, viral infection and chemical insults are common pathogenic factors of liver-related diseases that usually cause tissue damage and cell death, providing numerous danger signals for the activation of NLRP3 inflammasome. Currently, natural products have attracted much attention as potential agents for the prevention and treatment of liver diseases due to their multitargets and nontoxic natures. A great number of natural products have been shown to exhibit beneficial effects on liver injury induced by various chemicals through regulating NLRP3 inflammasome pathways. In this review, the roles of the NLRP3 inflammasome in chemical-induced liver injury (CILI) and natural products that exhibit beneficial effects in CILI through the regulation of inflammasomes were systematically summarized.

KeywordAcute Liver Failure Chemical-induced Liver Injury Inflammation Natural Products Nlrp3 Inflammasome
DOI10.1016/j.phrs.2020.105388
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000615153300039
Scopus ID2-s2.0-85098644897
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWan,Jian Bo
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa, Macao SAR,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zou,Jian,Wang,Sheng Peng,Wang,Yi Tao,et al. Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury[J]. Pharmacological Research,2021,164.
APA Zou,Jian,Wang,Sheng Peng,Wang,Yi Tao,&Wan,Jian Bo.(2021).Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury.Pharmacological Research,164.
MLA Zou,Jian,et al."Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury".Pharmacological Research 164(2021).
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